Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease
Conclusions
Altogether, these data indicate that Axin2 limits Wnt/β-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/β-catenin signalling resulting from loss of Axin2 leads to progressive MVD.
Source: Cardiovascular Research - Category: Cardiology Authors: Hulin, A., Moore, V., James, J. M., Yutzey, K. E. Tags: Cardiac biology and remodelling Source Type: research
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