Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease

Conclusions Altogether, these data indicate that Axin2 limits Wnt/β-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/β-catenin signalling resulting from loss of Axin2 leads to progressive MVD.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Cardiac biology and remodelling Source Type: research