Role of microRNA-155 in the pathogenesis and treatment of psoriatic arthritis

Background: MicroRNAs (miRNAs) are small non-coding RNA sequences capable of binding to specific mRNAs by regulating the processes of growth, differentiation and apoptosis. Dysregulation of their function causes altered gene transcription processes and therefore is also precipitating cause of many disease processes. Psoriatic arthritis (AP) is a chronic inflammatory arthropathy the occurrence of which is related to levels of miRNAs “dysregulated” in multiple locations and in various forms. The miRNA-155 (miR-155) is a classic example of multi-functional miRNA responsible for controlling pathological processes that contribute to the development of the PA.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research