Acute Encephalitic Syndrome in Adults and its Correlation with Cytokine Levels in Serum and Cerebrospinal Fluid.

In this study, we assessed the serum and cerebrospinal fluid (CSF) levels of cytokines and their correlation with clinical symptoms. Patients with AES of less than 2 weeks duration underwent brain imaging followed by a CSF examination for routine parameters and viral studies. Cytokines IL-6, IL-10 and RANTES levels were assessed in the serum in all patients and in 50 CSF samples and compared with serum cytokine levels in 64 age and sex matched controls. Of the 87 AES patients, 13 had Japanese Encephalitis. Serum IL-6, IL-10 and RANTES were significantly elevated in patients of AES compared to control group. Serum IL-10 was significantly reduced while RANTES was significantly elevated in patients who died. CSF IL-6 and IL-10 were significantly elevated in Non JE group compared to JE patients. RANTES levels in CSF were high in patients who had no seizures. IL-10 exerts its anti-inflammatory effect by modulating the innate and adaptive immune responses, thus limiting the production of pro-inflammatory cytokines. Its higher levels are found to be protective in acute encephalitis. PMID: 28003589 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research