A case of rat bite fever caused by Streptobacillus moniliformis.

We report a case of rat bite fever (RBF) diagnosed by detection of Streptobacillus moniliformis from blood culture and synovial fluid. The patient was a 45-year-old man with alcoholic liver cirrhosis. He was bitten on his third finger by a rat, which was caught in a mousetrap installed in his house. After the bite, fever, rash and arthralgia developed over a period of about two weeks. The patient was admitted to our hospital and treated with combination of Ampicillin- Sulbactam (SAM), Vancomycin (VAN) and Minocycline (MIN). The Anaerobic/F resin blood culture bottle became positive with gram negative bacillus in overnight incubation. Thus, S. moniliformis infection was suspected, and VAN and MIN was stopped. On the eighth hospital day, the treatment was switched to oral Amoxicillin-Clavulanate acid (AMC), and the patient was discharged from the hospital. Subsequently, the organism was also detected from synovial fluid and identified as S. moniliformis by 16S rRNA sequencing analysis. PMID: 28003596 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research