A Critical Role for {beta}-Catenin in Modulating Levels of Insulin Secretion from {beta}-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization [Cell Biology]

In conclusion, we find that β-catenin levels modulate Ca2+-dependent insulin exocytosis under conditions of glucose, GLP-1, or KCl stimulation through a role in modulating insulin secretory vesicle localization and/or fusion via actin remodeling. These findings also provide insights as to how the overexpression of TCF7L2 may attenuate insulin secretion.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research