Comparison of susceptibility patterns using commercially available susceptibility testing methods performed on prevalent Candida species.

Comparison of susceptibility patterns using commercially available susceptibility testing methods performed on prevalent Candida species. J Med Microbiol. 2016 Nov 01;: Authors: Cretella D, Barber KE, King ST, Stover KR Abstract The rising rates of invasive fungal infections caused by non-albicans Candida and the increasing emergence of antifungal resistance complicate the management of invasive candidiasis. Accurate and timely antifungal susceptibility testing is critical to targeting antifungal therapy. The purpose of this study was to compare commercially available susceptibility testing methods using prospectively collected Candida isolates. Susceptibility testing was performed on 74 Candida isolates collected from July 2014-March 2015 using broth microdilution (BMD) according to the Clinical and Laboratory Standards Institute (CLSI) method, Etest, Vitek2 (YS-05), and Sensititre. Essential agreement (EA) and categorical agreement (CA) was assessed using the reference method. Of the 34 total blood isolates collected, Candida albicans compromised only 38% (13) of the Candida species with C. glabrata being nearly as prevalent (29%, 10). CA using Etest was 86% for fluconazole, 72% for caspofungin, 98% for micafungin, and 97% for anidulafungin. Vitek 2 CA was 90% for fluconazole and 98% for caspofungin. Sensititre CA was 93% for fluconazole, 98% for caspofungin, 98% for micafungin, and 100% for anidulafungin. Although our study tested...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research