Genomic characterization of two new Enterovirus types, EV-A114 and EV-A121.

Genomic characterization of two new Enterovirus types, EV-A114 and EV-A121. J Med Microbiol. 2016 Oct 28;: Authors: Deshpande JM, Sharma DK, Saxena VK, Shetty SA, Qureshi TH, Nalavade UP Abstract Enteroviruses cause a variety of illnesses of the gastrointestinal tract, central nervous system as well as cardiovascular system. Phylogenetic analysis of VP1 sequences has identified 106 different human enteroviruses classified into four enterovirus species within genus Enterovirus of the Picornaviridae family. It is likely that not all enterovirus types have been discovered. Between September 2013 and October 2014, stool samples of 6274 apparently healthy children up to 5 years of age residing in Gorakhpur district, Uttar Pradesh, India were screened for enteroviruses. Virus isolates obtained in RD and Hep-2c cells were identified by complete VP1 sequencing. Enteroviruses were isolated from 3042 samples. 87 different enterovirus types were identified. Two isolates with 71% and 74% nucleotide sequence similarity from all other known Enteroviruses were recognized as new types. In this paper we report identification and complete genome sequence analysis of these two isolates classified as EV-A114 and EV-A121. PMID: 27902407 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research