Prescribing of baclofen for alcohol dependence 'should be reconsidered'

(European College of Neuropsychopharmacology) The drug baclofen has received high visibility as a possible breakthrough treatment for alcohol dependence. Now a new randomised controlled trial from the University of Amsterdam found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments.
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

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CONCLUSION: DMA and PVA-F100 based novel co-processed excipient could be potentially useful for the development of solid supersaturated self-nanoemulsifying drug delivery system for enhancing dissolution of lipophilic drugs. PMID: 30444435 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Liver transplantation for severe alcoholic hepatitis remains controversial in the USA in patients without 6 months of sobriety. Can earlier transplantation provide good outcomes in these patients?Alcohol and Alcoholism
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Gastroenterology Journal Article Source Type: news
Publication date: Available online 17 November 2018Source: Food HydrocolloidsAuthor(s): Seyed Fakhreddin Hosseini, Zahra Nahvi, Mojgan ZandiAbstractElectrospun chitosan/poly(vinyl alcohol) (CS/PVA) fibrous mats encapsulating fish-purified antioxidant peptide (AOP) were successfully fabricated under the optimal conditions (flow rate = 0.2 mL/h, applied voltage = 15 kV, and tip-to-collector distance = 15 cm). The AOP-loaded electrospun fibers displayed uniform and bead-free nanostructures with fiber diameter ranging from 157.9 ± 28.8 to 195.5 ± 34.4 nm, indicating the miscibility of ...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
This article is devoted to colloidal aggregates formed in air-saturated water in the presence of 3–10 vol% ethanol, either without or with long-tailed hydrophobic dyes. In 5 × 10−6 M solution of n‑decylfluorescein or n‑decyleosin, particles with size of about 100–300 nm and PDI around 0.1–0.3 were observed by the dynamic light scattering method. Varying of pH and the dyes concentration is accompanied by measurements of visible absorption spectra, size distribution, and ζ-potential. The last parameter is strongly pH-dependent, with isoelectric point within the pH range of 3 t...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
ConclusionNewly developed emulgel may be recommended with zulal instead of traditionally used sufl with zulal. In future emulgel will provide a solution for topical delivery of hydrophobic drugs and more convenient dosage form to apply locally.
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionsIn line with prior research, comorbid mental disorders were common; however, sociodemographic correlates of LCA profiles were modest. The high level of comorbidity underscores the need to develop and test transdiagnostic approaches for treatment in college students.
Source: International Journal of Methods in Psychiatric Research - Category: Psychiatry Authors: Tags: SPECIAL ISSUE Source Type: research
A history of behaviorally contingent or noncontingent cocaine experience increased indices of PI3K activity within the ventromedial prefrontal cortex (vmPFC). Neuropharmacological inhibition of vmPFC PI3K activity reversed a cocaine ‐conditioned place‐preference in mice and blocked incubated cocaine‐seeking in rats. AbstractPhosphatidylinositide 3 ‐kinases (PI3Ks) are intracellular signal transducer enzymes that recruit protein kinase B (aka Akt) to the cell membrane, the subsequent activation of which regulates many cellular functions. PI3K/Akt activity is up‐regulated within mesocorticolimbic structures in anim...
Source: Addiction Biology - Category: Addiction Authors: Tags: ORIGINAL ARTICLE Source Type: research
Alcoholic liver disease (ALD), induced by long ‐term heavy alcohol consumption, encompasses a progressive clinical–histological spectrum of liver injuries from simple fatty liver to alcoholic hepatitis, hepatic fibrosis and cirrhosis. Excessive alcohol consumption may lead to extensive hepatocellular necrosis, and in severe cases to liver fa ilure.
Source: Journal of Digestive Diseases - Category: Gastroenterology Authors: Tags: Guidelines Source Type: research
In conclusion, ALBI score demonstrated significant predictive capabilities for survival in patients with compensated cirrhosis resected for hepatocellular carcinoma. PMID: 30431722 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Authors: Stjepanović M, Škodrić-Trifunović V, Radisavljević-Pavlović S, Roksandić-Milenković M, Milin-Lazović J, Babić U, Mašković J, Buha I, Stojković-Lalošević M, Stojković M, Mihailović-Vučinić V Abstract Currently, topical are studies that examine different reasons for delay of tuberculosis (TB) diagnosis and its impact on disease prognosis. The aim was to examine three time periods associated with treatment delay: patient related, health system related and total delay. This retrospective-prospective study included 100 consecutive patients hospitalized at Department of Pulmo...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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