Prescribing of baclofen for alcohol dependence 'should be reconsidered'

(European College of Neuropsychopharmacology) The drug baclofen has received high visibility as a possible breakthrough treatment for alcohol dependence. Now a new randomised controlled trial from the University of Amsterdam found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments.
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

Related Links:

CONCLUSIONS: The suppression of Fas receptor signaling subsequent RNAi therapy may represent an applicable strategy to decline hepatocyte damages and so NASH progression in mice. PMID: 31010354 [PubMed - as supplied by publisher]
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Over the past decade, our field has observed rapidly rising rates of mental illness in children and adolescents. The numbers are sobering. Nearly 50% of teens 13 to 18 years of age meet DSM criteria for at least 1 disorder and 27.6% meet criteria for a “severe disorder.”1 Adverse childhood experiences affect more than 50% of children and predispose these individuals to not only academic and behavioral problems throughout their youth, but also future physical disability, such as obesity, hypertension, and diabetes, as adults.2 By 14 years of ag e, accidents, suicide, and homicide assert themselves as the leading...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
In their study, “State Level Firearm Concealed Carry Legislation and Rates of Homicide and Other Violent Crime,” Hamill and colleagues1 attempt to answer the question of whether increased numbers of individuals carrying concealed weapons would result in increased gun violence. The authors state that their stati stical technique is sufficiently rigorous to answer this question definitively and, as a result of their findings, that a recommendation to de-emphasize the role of concealed-carry in gun violence should be adopted by the surgical community.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
Conclusion: These findings support the hypothesis that in FM a deteriorated function of cortical inhibition, indexed by a higher SICI parameter, a lower function of the DPMS, together with a higher level of BDNF indicate that FM has different pathological substrates from depression. They suggest that an up-regulation phenomenon of intracortical inhibitory networks associated with a disruption of the DPMS function occurs in FM. Introduction Major depressive disorder (MDD) and fibromyalgia (FM) present overlapped symptoms. Although the connection between these two disorders has not been elucidated yet, the disruption...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion: Fat fraction on MRI corresponded to fat content on histology and therefore contributes to lesion characterization. Measurement repeatability was excellent for ADC; this parameter increased significantly post-radiotherapy even in disease categorized as stable by size criteria, and corresponded to cellularity on histology. ADC can be utilized for characterizing and assessing response in heterogeneous retroperitoneal sarcomas. Introduction Soft-tissue sarcomas are often highly heterogeneous tumors with variable components that can include cellular tumor, fat, necrosis, and cystic change. In many soft-tissue ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion Several TISC-based immunotherapeutic approaches are under development in various stages of preclinical studies. As outlined in this review article, a careful and more exhaustive genetic and metabolic understanding of TISC-associated phenotypes is critical to develop novel TISC based immunotherapies. Various components within the tumor microenvironment such as tumor cells, infiltrating immune cells, and supporting stromal cells impact the TISC metabolism. This unique metabolic profile leads to upregulation of certain enzymes and proteins such as ALDH1, CEP55, IDO COA1 etc., which can be utilized for development ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study is … the first, to our knowledge, to describe the correlates of subsequent injurious violence among patients being treated for schizophrenia in which the independent variables include recent violence toward others,” wrote Alec Buchanan, Ph.D., M.D, of Yale University School of Medi cine and colleagues.The analysis included 1,435 participants in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. Researchers assessed participants ’ clinical condition and violent behavior at baseline and every six months for the duration of the 18-month study.Violent behavior was self-...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance Alec Buchanan CATIE medication adherence schizophrenia violence Yale Source Type: research
Publication date: Available online 23 April 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): F. Rubin, O. Laccourreye
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - Category: ENT & OMF Source Type: research
Terra firma-forme dermatosis (TFFD) is a little-known disease of unknown etiology that clinically presents with asymptomatic brown to black plaques and resembles dirty skin. Here, we report the case of a 38-year-old woman with skin changes on her areolae that were mistakenly diagnosed as “dermatitis neglecta” by several physicians. Cleansing with water and soap had no impact on the skin appearance. But a swab of 70% isopropyl alcohol removed the plaques immediately, which confirmed the diagnosis of TFFD. Only a few cases of TFFD have been published, and this skin condition is no t mentioned in many textbooks. G...
Source: Case Reports in Dermatology - Category: Dermatology Source Type: research
More News: Alcoholism | Baclofen | International Medicine & Public Health | Neurology | Neuroscience | Science