Prescribing of baclofen for alcohol dependence 'should be reconsidered'

(European College of Neuropsychopharmacology) The drug baclofen has received high visibility as a possible breakthrough treatment for alcohol dependence. Now a new randomised controlled trial from the University of Amsterdam found no evidence for the usefulness of high-dose baclofen in treating alcoholism when added to psychosocial treatments.
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

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Publication date: Available online 19 July 2018Source: Journal of BiotechnologyAuthor(s): Henry Syukur Purwanto, Mi-Sook Kang, Lenny Ferrer, Sang-Soo Han, Jin-Young Lee, Hak-Sung Kim, Jin-Ho LeeAbstract4-Hydroxybenzoate (4HBA) is a valuable platform intermediate for the production of commodity and fine chemicals, including protocatechuate, cis,cis-muconic acid, adipic acid, terephthalic acid, phenol, vanillin, and 4-hydroxybenzyl alcohol glycoside (gastrodin). Here we describe rational engineering of the shikimate and related pathways in Corynebacterium glutamicum ATCC13032 for over-producing 4HBA. As an approach to increa...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
PURPOSE: The substantial literature showing that offspring of parents with alcohol use disorder (AUD) is at increased risk for externalizing psychopathology rarely examines the differential effects of parental and offspring sex. This literature also has ot...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
AbstractPurposeQuality assurance is much more difficult to achieve in surgical oncology than in medical oncology and radiotherapy where doses are standardized and toxicities are well-classified. To better define what is required in surgery, we analyzed recent articles addressing the point in head and neck surgery.ResultsThe surgical report should match with the pathological description of the resected specimen with accurate delineation of the margins, number and level(s) of lymph nodes (capsular rupture if any). Complications (minor and major) should be standardized and meticulously recorded; as well as comorbidities and p...
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
ConclusionAmong ED patients with acute nausea and not requiring immediate intravenous access, aromatherapy with or without oral ondansetron provides greater nausea relief than oral ondansetron alone.
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
ConclusionThe prevalence of agitation in the ED was 2.6%. Agitated patients frequently required restraint and sedation, with significant rates of clinical events requiring intervention.
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
We presented the first study utilizing both conventional and new analytics including ensemble method and predictive modeling based on smallest errors to predict BC risks. Predictive modeling of Generalized Regression Elastic Net Leave-One-Out demonstrated alcohol use (p = 0.0126) and age (p
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 19 July 2018Source: Journal of Molecular SpectroscopyAuthor(s): Colton D. Carlson, Nathan A. Seifert, Matthias Heger, Fan Xie, Javix Thomas, Yunjie XuAbstractThe rotational spectrum of 1-phenyl-2,2,2-trifluoroethanol, a chiral organic alcohol, was investigated using two chirped pulse Fourier transform microwave spectrometers. The molecule is a derivate of 2,2,2-trifluoroethanol, and the phenyl substitution plays a major role in altering the conformational landscape. Three equilibrium minima were identified at the MP2 and B3LYP-D3BJ levels of theory, of which only two exist as stable confo...
Source: Journal of Molecular Spectroscopy - Category: Molecular Biology Source Type: research
(Natural News) The United States is home to virtually as many cars as people, with its 318 million residents owning an estimated 260 million vehicles. As noted by the website, if you’re American and you don’t own a car, “people usually think you’re a hippy or an alcoholic.” Those millions and millions of vehicles...
Source: - Category: Consumer Health News Source Type: news
(Reuters Health) - Drinking alcohol and smoking pot at the same time is more likely to increase the odds of unsafe sex for young women than for men, a small U.S. study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Yanfang Zhao, Chao Chang, Panpan Gai, Lei Han, Feng Li, Bo LiAbstractIn this work, we develop a facile one-step synthesis method of poly(3,4-dihydroxyphenylalanine) (poly(DOPA)) fluorescent organic nanoparticles (FONPs) by polymerization of DOPA in alkaline alcohol solution under ultrasonic radiation. The morphology and size of poly(DOPA)-FONPs are dependent on the synthesis conditions, such as solvent and alkali concentration. Under the optimized condition, the prepared poly(DOPA)-FONPs possess not only uniform size and morph...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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