Review: Cav2.3 R-type Voltage-Gated Ca(2+) Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity.

CONCLUSION: Development of novel Cav2.3 specific modulators can be effective in the pharmacological treatment of epilepsies and other neurological disorders. PMID: 27843503 [PubMed - in process]
Source: The Open Neurology Journal - Category: Neurology Tags: Open Neurol J Source Type: research

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AbstractThis is a letter to the Editor concerning the recently published article by Zerem et al. The paper described a 12yo female with multisystem mitochondrial disorder (MID) due to the compound heterozygous variants c.1963_1964dupAT and p.Ile382Met inOPA1 manifesting phenotypically with congenital nystagmus, developmental delay, visual impairment, gait ataxia, epilepsy, a stroke-like episode (SLE) with encephalopathy and vomiting, and hearing impairment. This interesting case could be more meaningful by providing more information about the treatment of the SLE/stroke-like lesion (SLL), about the morphological characteri...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
In conclusion, our kindling model demonstrates the ability of insular cortex stimulation to generate epilepsy. Our model thus offers a practical tool for studies of the role of the insular cortex in sudden unexpected death in epilepsy.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Conclusions: Psychiatric comorbidity is very common in epileptic patients and depending on the type of diagnosed epilepsy, various symptoms are expressed. Furthermore, psychological stress is more observable in adolescents with epilepsy. For patients with epilepsy, mental health care and seizure control is extremely important in the prevention of serious mental disabilities. PMID: 31961263 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): Rahul Sharma, Pradip Sircar, Ram Bilas PachoriAbstractEpilepsy is a chronic neurological disorder which occurs due to recurrent seizures. The epilepsy surgery is the only cure of epileptic seizures as it cannot be controlled with medication. Hence, it becomes the primary task to localize the epileptogenic zone for successful epilepsy surgery. The epileptic surgical area can be recognized by the focal intracranial electroencephalogram (EEG) signals. In this paper, a nonlinear third-order cumulant has been proposed for the class...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Purpose: Mesial temporal lobe epilepsy (MTLE) and Alzheimer's disease (AD) are two distinct neurological disorders associated with hippocampal atrophy. Our goal is to analyze the morphologic patterns of hippocampal atrophy to better understand the underlying pathological and clinical characteristics of the two conditions.Methods: Twenty-five patients with AD and 20 healthy controls with matched age and gender were recruited into the AD group. Twenty-three MTLE patients and 28 healthy controls with matched age and gender were recruited into the MTLE group. All subjects were scanned on 3T-MRI scanner. Automated volumetric an...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we examine risk factors and consequences of intravenous rt-PA for treatment of acute ischemic stroke. In a retrospective cohort study we evaluate risk factors for seizure and epilepsy after stroke thrombolysis, as well as the impact of seizures and epilepsy in outcome of stroke patients. In our cohort, mean age of patients was 67.2 years old (SD = 13.1) and 79 of them (51.6%) were male and. Initial NIHSS mean score were 10.95 (SD = 6.25). Three months NIHSS mean score was 2.09 (SD = 3.55). Eighty seven (56.9%) patients were mRS of 0–1 after thrombolysis. Hemorrhagic transformation was observed in 22 (1...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionThis study demonstrated that a good quality of life was observed among the majority of CWE and their caregivers, although some factors such as a male caregiver gender and lower level of education were associated with poor QoL.
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 21 January 2020Source: SeizureAuthor(s): Petra Redfors, Lukas Holmegaard, Annie Pedersen, Christina Jern, Kristina MalmgrenAbstractPurposeTo assess long-term incidence and predictors of post-stroke epilepsy (PSE) and to evaluate the antiepileptic drug (AED) treatment in a well characterized cohort of middle-aged patients.MethodsThe study is based on the Sahlgrenska Study on Ischemic stroke, and included 1066 adult patients with first-ever or recurrent acute ischemic stroke (AIS) before the age of 70. Early seizures (ES) were defined as seizures within one week and PSE as unprovoked seizur...
Source: Seizure - Category: Neurology Source Type: research
ConclusionsExpression of SSTRs and activation of mTOR pathway in paediatric glioneuronal tumour suggest that somatostatin analogues and mTOR inhibitors may have potential therapeutic implications in a subset of inoperable childhood glioneuronal tumours causing medically refractory epilepsy and/or tumour growth. Further clinical studies are warranted to validate these findings.
Source: Seizure - Category: Neurology Source Type: research
ConclusionComorbidity increased the rate of all-cause, but not MS-specific, hospital admissions. Hospitalization rates were higher during the earlier stages of MS. Therefore, recognizing and managing comorbidity in the MS population, especially early in the disease course, will likely have the biggest impact on reducing overall hospital admissions.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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