Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow

In conclusion, ablation of systemic MMP-9 initiated fatal communication between maintenance of physiological functions of MMP-9 in the bone marrow and invasive growth of PDAC via the IL6/IL6R/STAT3 axis. Implications: Thus, the beneficial effects of host MMP-9 on PDAC are an important caveat for the use of systemic MMP-9 inhibitors in cancer. Mol Cancer Res; 14(11); 1147–58. ©2016 AACR.

http://mcr.aacrjournals.org/cgi/content/short/14/11/1147?rss=1

Source: Molecular Cancer Research - November 9, 2016 Category: Cancer & Oncology Authors: Grünwald, B., Vandooren, J., Gerg, M., Ahomaa, K., Hunger, A., Berchtold, S., Akbareian, S., Schaten, S., Knolle, P., Edwards, D. R., Opdenakker, G., Krüger, A. Tags: Signal Transduction Source Type: research