Back to the Future. Vaccine trials against Ebola in the history of resistance to immunization.
This article offers a retrospective view on the resistances to vaccination throughout its history, from smallpox inoculation to anti-polio vaccine. Resistances have been linked to the political contexts and the rejection of an oppressive power, either local or foreign, as well as mistakes and scientific uncertainties. The analysis of the historical factors of resistance leads to reverse the question: what convinces people to accept a vaccine trial, despite the obscurities of the immunization processes inside the body? The article hypothesizes that Guineans and West Africans face a dilemma similar to their counterparts in the past, whether or not to rally to an experimental immunization, the results of which are still pending. They may appropriate the Western beliefs about the efficacy of vaccines to their own ways of circumventing misfortune. Further field studies will be required to assess the role of the vaccinal trials and the response to the epidemic in the "convalescence" of these societies, being aware that the trials will not allow a complete assessment of the vaccines, because of the end of the epidemic. PMID: 27686081 [PubMed - as supplied by publisher]
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Annelies Wilder-Smith, Stefan Flasche, Peter G Smith
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Basu Dev Pandey, Anthony Costello
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Mohammed A Mamun, Jannatul Mawa Misti, Mark D Griffiths, David Gozal
ConclusionThe present study reports a variant subgroup GII-a PEDV HM2017 strain in China and characterize its pathogenicity. PEDV strain HM2017 of subgroup GII-a presents a promising vaccine candidate for the control of PED outbreaks in China.
In this study H. pylori CagL gene was cloned in pAMJ2008 vector and transferred to Lactococcus lactis MG1363 as the host for CagL antigen production. This recombinant bacterium was orally subjected to mice, and the immune response to CagL was evaluated by ELISA. Intracellular expression of CagL protein was confirmed by Western blot analysis. Mucosal immunization of mice with the recombinant L. lactis significantly stimulated CagL-Specific antibodies: IgA, IgG, cytokine IL-17 and IN-γ. Moreover, the specific anti-CagL IgA response was detected in the feces of immunized mice. These results indicate that CagL of H. pylo...
Publication date: Available online 13 December 2019Source: Journal of Hospital InfectionAuthor(s): Helena C. Maltezou, Xanthi Dedoukou, Elpida Pavi, Maria Thoeodoridou, Kostas AthanasakisSummaryMeasles represents an occupational risk for healthcare personnel (HCP). A total of 117 cases of measles among HCP were notified in Greece during 2017-2018. We were able to contact 46 of them. Most of those contacted had a serious clinical course with complications, necessitating hospitalization in 67% of cases. All HCP reported absenteeism, for a mean duration of 21.2 working days (range: 3-60 days); 54.3% of HCP reported being at w...
ConclusionsThis study provides initial perspectives on measles preparedness among Idaho CAHs, despite limited generalizability. Future studies should explore whether self-reported preparedness measures reflect the ability of the CAHs to control measles spread when cases present for care.
A financially troubled Seattle research institute cut back programs, leaving researchers to find new homes for work on infectious diseases like tuberculosis and leprosy.
(CNN/CBS) — At least 1,300 people have died from the flu so far this season, according to a preliminary estimate released Friday by the US Centers for Disease Control and Prevention. There have been at least 2.6 million flu illnesses and 23,000 flu-related hospitalizations, according to the analysis. So far this season, the CDC has received reports of 10 children who have died from the flu, four more than the week before. Experts have warned that flu is hitting the United States early this year, and there are concerns that this early season could mean a particularly severe season overall. Flu spread significantly in ...
Publication date: Available online 12 December 2019Source: American Heart JournalAuthor(s): Mark Loeb, Hisham Dokainish, Antonio Dans, Lia M Palileo-Villanueva, Ambuj Roy, Kamilu Karaye, Jun Zhu, Yan Liang, Fastone Goma, Albertino Damasceno, Khalid F AlHabib, Gerald Yonga, Charles Mondo, Wael Almahmeed, Arif Al Mulla, Salim Yusuf, IVVE investigators