Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

Conclusion
Elevated wall stress reduces junctophilin-2 expression and disrupts t-tubule integrity, Ca2+ release, and contractile function. These findings provide new insight into the role of wall stress in promoting heart failure progression.

Source: Cardiovascular Research - September 21, 2016 Category: Cardiology Authors: Frisk, M., Ruud, M., Espe, E. K. S., Aronsen, J. M., Roe, A. T., Zhang, L., Norseng, P. A., Sejersted, O. M., Christensen, G. A., Sjaastad, I., Louch, W. E. Tags: Cardiac biology and remodelling Source Type: research