α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.

This study therefore shows for the first time that misfolded α-synuclein can interact and affect the cerebral endothelial system, although its relevance to the pathogenesis of Parkinson's disease remains to be elucidated. PMID: 27632900 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/27632900?dopt=Abstract

Source: Experimental Neurology - September 11, 2016 Category: Neurology Authors: Kuan WL, Bennett N, He X, Skepper JN, Martynyuk N, Wijeyekoon R, Moghe PV, Williams-Gray CH, Barker RA Tags: Exp Neurol Source Type: research