Increased bone marrow iron scores (BMIS) are strongly correlated with elevated serum ferritin levels and poorer survival in patients with iron overload that underwent allogeneic hematopoietic stem cell transplantation (alloHSCT): A single center experience

Conclusion The validation of BMIS for risk stratification in patients who undergo allogeneic hematopoietic stem cell transplantation may predict post-transplant outcomes. Teaser Iron overload (IO) is one of the most important complications of chronic red blood cell transfusions in patients that receive chemotherapy or undergo hematopoieteic stem cell transplantation (HSCT). Bone marrow is among the major sites of IO. So; this study showed that increased bone marrow iron content might predict poor survival in alloHSCT recipients and that bone marrow evaluations prior to transplantation would be a valuable method to diagnose IO.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research