169 Regeneration of a functional epidermis at a large, long-standing wound by gene-corrected autologous epidermal stem cells

We here report on the first patient affected by the genetic skin disease junctional epidermolysis bullosa (JEB), in whom an autologous cell and gene therapy product has been transplanted onto a non-healing epidermal ulceration. The whole study was carried out following a GMP protocol. A 49-years old patient affected by JEB, LAMB3 reduced, was suffering from a large ulceration on her right calf for 10 years accompanied by recurrent infections and fluid loss despite extensive conservative therapy.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetics and Cell Based Therapy Source Type: research