Comment: Dissecting the genetic architecture of Tourette syndrome into subphenotypes

Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder marked by multiple motor and vocal tics and a waxing and waning course. Although the genetic basis of TS remains elusive, multiple genes and interacting environmental factors are likely involved.1 Our search for the TS genetic component is hampered by its phenotypic complexity; TS is characterized by a broad spectrum of simple to complex tics, and up to 90% of patients also exhibit psychiatric comorbidities such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism spectrum disorders.2 This great phenotypic heterogeneity may also be accompanied by etiologic heterogeneity.
Source: Neurology - Category: Neurology Authors: Tags: Tics, Child psychiatry, All Psychiatric disorders, ADHD, All Genetics ARTICLE Source Type: research