Paradoxical effects of Auger electron-emitting 111In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45+ cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice

111In-DTPA-NLS-CSL360 radioimmunoconjugates (RIC) recognize the overexpression of the interleukin-3 receptor α-subchain (CD123) relative to the β-subchain (CD131) on leukemia stem cells (LSC). Our aim was to study Auger electron radioimmunotherapy (RIT) of acute myeloid leukemia (AML) with 111In-DTPA-NLS-CSL360 in non-obese diabetic severe combined immunodeficiency (NOD/SCID) mice or NOD-Rag1nullIL2rγnu ll (NRG) mice engrafted with CD123+ human AML-5 cells.

Source: Nuclear Medicine and Biology - July 20, 2016 Category: Nuclear Medicine Authors: Dane Bergstrom, Jeffrey V. Leyon, Arman Zereshkian, Conrad Chan, Zhongli Cai, Raymond M. Reilly Source Type: research