Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study

GPR120 (encoded by FFAR4) is a lipid sensor that plays an important role in the control of energy balance. GPR120 is activated by long chain fatty acids (FAs) including omega-3 FAs. In humans, the loss of function p.R270H variant of the gene FFAR4 has been associated with a lower protein activity, an increased risk of obesity and higher fasting plasma glucose levels.The aim of this study was to investigate whether p.R270H interacts with dietary fat intake to modulate the risk of type 2 diabetes (T2D, 198 incident; 368 prevalent cases) and overweight (787 incident and 2891 prevalent cases) in the prospective D.E.S.I.R.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 24, 2016 Category: Nutrition Authors: A. Lamri, A. Bonnefond, D. Meyre, B. Balkau, R. Roussel, M. Marre, P. Froguel, F. Fumeron, the D.E.S.I.R. Study Group Source Type: research