Canonical Wnt/ β-catenin signaling pathway is dysregulated in patients with primary and secondary myelofibrosis

Conclusion Present study shows for the first time that β-catenin mRNA expression is increased in patients with both PMF and SMF and its upregulation might potentiate anemia. Number of inflammatory cytokines associated with PMF are capable of mediating their effects through increased β-catenin expression. Accordingly, β-catenin can induce expression of number of genes implicated in processes of cell cycle control, fibrosis and angiogenesis which are central to the PMF pathogenesis. Therefore, β-catenin may represent interesting new therapeutic target in these diseases. Graphical abstract Teaser Activation of Wnt/β-catenin signaling pathway is associated with malignant transformation, development of fibrosis and angiogenesis. We analyzed β-catenin mRNA expression in bone marrows of 29 patients with primary (PMF), four with secondary myelofibrosis (SMF) and 16 controls using qRT-PCR. Β-catenin expression is increased in both PMF and SMF and might potentiate anemia.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research