Abstract < /h3 > < span class= " a-plus-plus abstract-section id-a-sec1 " > < h3 class= " a-plus-plus " > Purpose of Review < /h3 > < p class= " a-plus-plus " > Epithelial cells line tissues and serve an important functional role in maintaining a barrier between tissue compartments and protection from the external environment. Tight Junctions and apical –basal polar..."> Abstract < /h3 > < span class= " a-plus-plus abstract-section id-a-sec1 " > < h3 class= " a-plus-plus " > Purpose of Review < /h3 > < p class= " a-plus-plus " > Epithelial cells line tissues and serve an important functional role in maintaining a barrier between tissue compartments and protection from the external environment. Tight Junctions and apical –basal polar..." /> Abstract < /h3 > < span class= " a-plus-plus abstract-section id-a-sec1 " > < h3 class= " a-plus-plus " > Purpose of Review < /h3 > < p class= " a-plus-plus " > Epithelial cells line tissues and serve an important functional role in maintaining a barrier between tissue compartments and protection from the external environment. Tight Junctions and apical –basal polar..." />

Apical –Basal Polarity as a Sensor for Epithelial Homeostasis: A Matter of Life and Death

< h3 class= " a-plus-plus " > Abstract < /h3 > < span class= " a-plus-plus abstract-section id-a-sec1 " > < h3 class= " a-plus-plus " > Purpose of Review < /h3 > < p class= " a-plus-plus " > Epithelial cells line tissues and serve an important functional role in maintaining a barrier between tissue compartments and protection from the external environment. Tight Junctions and apical –basal polarity function to establish and maintain epithelial structures to prevent leakage between cells and define distinct subcellular domains to localize signaling pathways within cells that control growth, survival, and migration. Disruption of tight junctions and cell polarity is frequently observed in cancer. < /p > < /span > < span class= " a-plus-plus abstract-section id-a-sec2 " > < h3 class= " a-plus-plus " > Recent Findings < /h3 > < p class= " a-plus-plus " > In this review, we discuss a role for Tight Junctions and the Par polarity complex as a sensor of epithelial integrity that contributes to maintaining epithelial homeostasis through apoptosis, proliferation, and stem cell renewal, and that disruption of these processes contributes to cancer progression. < /p > < /span > < span class= " a-plus-plus abstract-section id-a-sec3 " > < h3 class= " a-plus-plus " > Summary < /h3 > < p class= " a-plus-plus " > Epithelial homeostasis is maintained by the spatial organization of signaling pathways within cells. Damaged cells are eliminated from the tissue by extrusion and apoptosis, and a...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research