Searching for convergent pathways in autism spectrum disorders: insights from human brain transcriptome studies.

Searching for convergent pathways in autism spectrum disorders: insights from human brain transcriptome studies.
Cell Mol Life Sci. 2016 Jul 12;
Authors: Gokoolparsadh A, Sutton GJ, Charamko A, Green NF, Pardy CJ, Voineagu I
Abstract
Autism spectrum disorder (ASD) is one of the most heritable neuropsychiatric conditions. The complex genetic landscape of the disorder includes both common and rare variants at hundreds of genetic loci. This marked heterogeneity has thus far hampered efforts to develop genetic diagnostic panels and targeted pharmacological therapies. Here, we give an overview of the current literature on the genetic basis of ASD, and review recent human brain transcriptome studies and their role in identifying convergent pathways downstream of the heterogeneous genetic variants. We also discuss emerging evidence on the involvement of non-coding genomic regions and non-coding RNAs in ASD.
PMID: 27405608 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - July 11, 2016 Category: Cytology Authors: Gokoolparsadh A, Sutton GJ, Charamko A, Green NF, Pardy CJ, Voineagu I Tags: Cell Mol Life Sci Source Type: research