Development of the Gabriella Miller Kids First Pediatric Data Resource Center (U2C)

The objective of this FOA is to support the development of the Data Resource Center for the Gabriella Miller Kids First Pediatric Research Program (Kids First), which consists of the following components: a web-based Data Resource Portal, a Data Coordination Center, and Administrative and Outreach Core. The goal of the Data Resource Portal is to accelerate discovery of genetic etiology and shared biologic pathways within and across childhood cancers and structural birth defects by facilitating access to and querying of annotated genomic sequence and phenotypic data from cohorts of patients with these conditions. The Data Resource Portal will serve as an indispensable research resource where genomic data can be aggregated, accessed, analyzed, and shared within and across the childhood cancer and birth defects research communities as well as the broader scientific community. The Data Coordination Center will work with Kids First investigators and sequencing centers to facilitate data collection and harmonization. The Administrative and Outreach Core will oversee administrative activities, work closely with a Steering Committee, and provide outreach and education to the research community on using the Data Resource Portal.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

Related Links:

Conclusion: Survivors of hepatoblastoma are at risk for long-term complications. They require long-term monitoring for late effects.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsThe LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.
Source: American Heart Journal - Category: Cardiology Source Type: research
(American College of Allergy, Asthma, and Immunology) New study being presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Houston shows an association between a family history of cancer and a childhood asthma diagnosis.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Authors: Flynn SM, Lesperance J, Macias A, Phanhthilath N, Paul MR, Kim JW, Tamayo P, Zage PE Abstract Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk and relapsed tumors. Inhibitors of the RET kinase and the RAS-MAPK pathway have previously been shown to be effective against neuroblastoma, suggesting that combined inhibition may have increased efficacy. RXDX-105 is a small molecule inhibitor of multiple kinases, including the RET and BRAF kinases. We found tha...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Merker M, Meister MT, Heinze A, Jarisch A, Sörensen J, Huenecke S, Bremm M, Cappel C, Klingebiel T, Bader P, Rettinger E Abstract Prognosis of refractory childhood cancers despite multimodal treatment strategies remains poor. Here, we report a single center experience encountered in 18 patients with refractory solid malignancies treated with adoptive cellular immunotherapy (ACI) from haploidentical or matched donors following hematopoietic stem cell transplantation. While seven patients were in partial and six in complete remission (CR), five patients suffered from relapsed diseases at the time of ACI...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
The WHO Global Initiative for Childhood Cancer launched in 2018 will translate into an additional one million lives saved or a survival rate of at least 60% for children with cancer to be attained by 2030. Thi...
Source: Infectious Agents and Cancer - Category: Cancer & Oncology Authors: Tags: Commentary Source Type: research
CONCLUSIONS AND IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: Efforts that prevent adverse childhood experiences could also potentially prevent adult chronic conditions, depression, health risk behaviors, and negative socioeconomic outcomes. States can use comprehensive public health approaches derived from the best available evidence to prevent childhood adversity before it begins. By creating the conditions for healthy communities and focusing on primary prevention, it is possible to reduce risk for adverse childhood experiences while also mitigating consequences for those already affected by these experiences. PMID: 316...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
The objective of this study is to map evidence on the distribution of paediatric cancers in the SSA region.MethodA scoping review will be conducted to map literature on the distribution of paediatric cancers in SSA. An electronic literature search will be conducted from the following databases: PubMed, Google Scholar, EBSCOhost (CINAHL and Health Source) and World Health Organization (WHO)/International Agency for Research in Cancer (IARC) (GLOBOCAN databases). We will also search the reference lists of included studies to source relevant literature. A pilot search was conducted to determine the feasibility of the study. S...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Publication date: 5 November 2019Source: Cell Reports, Volume 29, Issue 6Author(s): Jo Lynne Rokita, Komal S. Rathi, Maria F. Cardenas, Kristen A. Upton, Joy Jayaseelan, Katherine L. Cross, Jacob Pfeil, Laura E. Egolf, Gregory P. Way, Alvin Farrel, Nathan M. Kendsersky, Khushbu Patel, Krutika S. Gaonkar, Apexa Modi, Esther R. Berko, Gonzalo Lopez, Zalman Vaksman, Chelsea Mayoh, Jonas Nance, Kristyn McCoySummaryAccelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and...
Source: Cell Reports - Category: Cytology Source Type: research
This study presents results of the second follow-up for the risk of childhood cancer in a cohort of children (
Source: Journal of Radiological Protection - Category: Physics Authors: Source Type: research
More News: Cancer | Cancer & Oncology | Child Development | Childhood Cancer | Children | Contracts | Education | Funding | Genetics | Grants | Pediatrics | Research | Universities & Medical Training