Effect of cholesterol medicine on inflammatory diseases mapped

The cholesterol medicine simvastatin, which is one of the most commonly used pharmaceuticals in the world, also has a beneficial effect on the immune defense system with regard to diseases such as type 1 diabetes, multiple sclerosis and rheumatoid arthritis. Researchers have now explored why this is so, and their findings may result in improved treatment.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: September 2018Source: Advances in Medical Sciences, Volume 63, Issue 2Author(s): Małgorzata Wilusz, Dominik Cieniawski, Grzegorz Wasilewski, Marek Kuźniewski, Władysław Sułowicz, Krystyna SztefkoAbstractPurposeDiabetes mellitus and hyperlipidemia are frequently observed after organ transplantation. It is known that in these disorders the fatty acid metabolism is impaired. The aim of this study was to compare the fatty acid profile in the heart and renal transplant recipients who developed metabolic disorders since there is no such research available.Materials and methodsThe study included 55 patients...
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Authors: Xu Y, Li Z Abstract Adenosine triphosphate-binding cassette transporter A1 (ABCA1) gene polymorphism in lacunar infarction (LI) combined with arteriosclerosis was investigated. A total of 112 LI patients complicated with arteriosclerosis treated in Ningbo First Hospital from March 2015 to September 2016 were enrolled as observation group. At the same time, 342 healthy subjects were selected from physical examination center to serve as the control group. The ABCA1 gene polymorphism was detected via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the susceptibility of ABCA1...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Cai X, Wang L, Wang X, Hou F Abstract Insulin-like growth factor-binding protein 7 (IGFBP7) has been identified as a secreted protein associated with a number of cellular processes. However, the specific regulatory mechanisms of IGFBP7 on podocytes of diabetic nephropathy (DN) are yet to be elucidated. In the present study, podocytes were identified initially via an immunofluorescence assay using an anti-synaptopodin antibody. It was subsequently demonstrated that glucose promoted podocyte proliferation in a time- and dose-dependent manner via MTT assay. In addition, IGFBP7 expression was silenced in podoc...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
In conclusion, the data identified the IRE1α-Xbp1 signaling pathway as an essential mediator that associates EX-4 with the intracellular mechanism that inhibits ER stress and activates Akt in order to regulate β cell survival. This may provide important evidence for the use of EX-4 in treatments for type 2 diabetes. PMID: 30112049 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 17 August 2018Source: Journal of Visceral SurgeryAuthor(s): B. Le Roy, A. Dupré, A. Gallon, P. Chabrot, J. Gagnière, E. BucSummaryVarious procedures can promote hypertrophy of the future liver remnant (FLR) before major hepatectomy to prevent postoperative liver failure. The pathophysiological situation following portal vein embolization (PVE), hepatic artery ligation/embolization or hepatectomy remains unclear. On one hand, the main mechanisms of hepatic regeneration appear to be driven by hepatic hypoxia (involving the hepatic arterial buffer response), an increased portal...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
ConclusionsThis study suggests that there is no relationship between arterial stiffness and aerobic capacity in healthy young adults.
Source: Journal of Exercise Science and Fitness - Category: Sports Medicine Source Type: research
ConclusionsAlthough there was an acceptable correlation between the presence of subclinical atherosclerosis and SCOREM, there was a considerable proportion of atheromatous plaques in low-risk patients. Disease activity was the risk factor most closely associated with increased CVR.ResumenLa artritis reumatoide (AR) presenta una mortalidad de 1,3 a 3 veces superior a la población general; la principal causa de muerte son las complicaciones cardiovasculares (40-50%). En el abordaje inicial se debe incluir la valoración del riesgo cardiovascular (RCV) mediante algoritmos adaptados para esta población. Si ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
ConclusionsRheumatologists are the main and most reliable source of information for patients with spondyloarthritis and psoriatic arthritis. Patient associations have an important role and are well regarded. Changes in the content, format and sources of information are required.ResumenObjetivo1. Describir la información que reciben o buscan los pacientes con espondiloartritis axial y artritis psoriásica. 2. Analizar fórmulas para mejorar la misma.MétodosAnálisis cualitativo del discurso en grupos focales (con pacientes asociados y no asociados y reumatólogos) para identificar los e...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
ConclusionsWe present the update of SER recommendations for the treatment of PsA with DMARDs and biologics.ResumenObjetivoLa primera finalidad de este documento de recomendaciones es proporcionar al clínico la mejor evidencia disponible y, en su defecto, la mejor opinión consensuada por los panelistas para un uso racional y fundado de las diversas opciones de tratamiento con fármacos antirreumáticos modificadores de la enfermedad (FAME) sintéticos y biológicos en artropatía psoriásica (APs). El presente documento también incide sobre aspectos importantes en el ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Laura has not only lost a substantial amount of weight from inflammatory visceral fat resulting in a dramatic reduction in waist size, but has also experienced a reduction in the issues associated with her autoimmune diseases: “I have been on Wheat Belly for about 2 years. I have rheumatoid arthritis and lupus and have seen huge improvements and lowering of meds due to this wonderful plan. So far (and I still need to lose more) I have lost 80 lbs and am still losing. First pic is of me at our high school reunion in 2013 and the next one is today. I think you can see a bit of the difference. I am happy to be down, eve...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories arthritis autoimmune gluten grains lupus rheumatoid Weight Loss Source Type: blogs
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