Effect of cholesterol medicine on inflammatory diseases mapped

The cholesterol medicine simvastatin, which is one of the most commonly used pharmaceuticals in the world, also has a beneficial effect on the immune defense system with regard to diseases such as type 1 diabetes, multiple sclerosis and rheumatoid arthritis. Researchers have now explored why this is so, and their findings may result in improved treatment.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSIONS: Whilst no model can fully represent a disease, a DES allows an opportunity to include features excluded in a Markov structure. A DES may be more suitable for modelling in RRMS for health technology assessment purposes given the complexity of some DMTs. This analysis highlights the capabilities of different model structures to model event-triggered attributes. PMID: 29923439 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
In conclusion, HlMeOHe damaged the liver with an oral dose of 200 mg/kg, and at 1000 mg/kg injured the kidneys and pancreas of the CD-1 male mice. PMID: 29923593 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
In this study, a collagen-induced arthritis (CIA) model was established to simulate rheumatoid arthritis (RA) using two intradermal injections of bovine type II collagen and Freund’s complete adjuvant mixture given at two-week intervals. Subsequently, the transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) was used to treat RA and the treatment efficacy, as well as the possible regulatory mechanism underlying hUC-MSC transplantation, was observed. During the study, forty rats were randomly divided into four groups and their blood samples were collected at different time points to measure levels of se...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Effects of soybean isoflavones on Wnt/β-catenin and the TGF-β1 signaling pathway in renal tissue of type 2 diabetic rats. J Biol Regul Homeost Agents. 2018 May-Jun;32(3):455-464 Authors: Liu CL, Yan L, Cai KR, Sun K, Qi Y, Han YL, Zhang XD, Sun XD Abstract To observe the effect of Soyisoflavones (SI) on the expression of Wnt/β-catenin signaling pathway elements, transforming growth factor-β (THGF-β) and its related proteins in the renal interstitia of diabetic nephropathic (DN) rats, 48 DN rats were randomly divided into 4 groups: DN model group (group DN), soybean isoflavone t...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Source: Primary Care Diabetes - Category: Primary Care Source Type: research
Source: Primary Care Diabetes - Category: Primary Care Source Type: research
Prevention of neonatal hypoglycemia and the associated neonatal intensive care unit (NICU) admissions in asymptomatic newborn infants is important in order to limit the separation of mothers and infants after birth, to promote breastfeeding, and to limit potential complications of hypoglycemia. After the success of clinical trials of dextrose gel for infants with asymptomatic hypoglycemia (Cochrane Database Syst Rev 2016:CD011027), a logical next step would be to administer prophylactic treatment to infants with perinatal risk factors such as maternal diabetes.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
The diagnosis of type 2 diabetes mellitus is often preceded by prediabetes, a stage during which blood glucose levels are greater than normal but not yet high enough to be diagnostic of diabetes.1 About 84 million people in the United States have prediabetes; a number equivalent to approximately one in three adults.1 Without intervention, an unknown, but likely significant proportion of these people will develop type 2 diabetes. However, the progression from prediabetes to type 2 diabetes is not inevitable and can be interrupted with diabetes prevention programs (DPPs) comprising low-cost, structured lifestyle change inter...
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Research Source Type: research
We congratulate the authors of the Summary of the NIDDK Diseases Workshop, entitled “EUS and related technologies for the diagnosis and treatment of pancreatic disease: research gaps and opportunities.”1,2 The brief history of EUS summarized in the first sentence, however, contains inaccuracies that cloud this history detailed in our recent reviews.3,4
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Laura has not only lost a substantial amount of weight from inflammatory visceral fat resulting in a dramatic reduction in waist size, but has also experienced a reduction in the issues associated with her autoimmune diseases: “I have been on Wheat Belly for about 2 years. I have rheumatoid arthritis and lupus and have seen huge improvements and lowering of meds due to this wonderful plan. So far (and I still need to lose more) I have lost 80 lbs and am still losing. First pic is of me at our high school reunion in 2013 and the next one is today. I think you can see a bit of the difference. I am happy to be down, eve...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories arthritis autoimmune gluten grains lupus rheumatoid Weight Loss Source Type: blogs
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