Effect of cholesterol medicine on inflammatory diseases mapped
The cholesterol medicine simvastatin, which is one of the most commonly used pharmaceuticals in the world, also has a beneficial effect on the immune defense system with regard to diseases such as type 1 diabetes, multiple sclerosis and rheumatoid arthritis. Researchers have now explored why this is so, and their findings may result in improved treatment.
Authors: Pintaudi B, Di Vieste G, Corrado F, Lucisano G, Giunta L, D'Anna R, Di Benedetto A Abstract OBJECTIVE: Myo-inositol supplementation prevents gestational diabetes (GDM) in women at risk and reduces insulin resistance in women with GDM. No data are available about its effect on glucose variability. The aim of this study was to evaluate the effects of a supplementation of myo-inositol on glucose variability in women with GDM. PATIENTS AND METHODS: Myo-inositol effect on glucose variability was studied in a pilot case-control study involving 12 consecutive pregnant women (median age 34 years, 25.0% insulin...
CONCLUSIONS: Aside from oxidative stress, LA possessed anti-inflammatory and immunomodulatory effects on EAE. LA might be a promising candidate for MS treatment. PMID: 30338822 [PubMed - in process]
Investigation for TGF-β1 expression in type 2 diabetes and protective effects of TGF-β1 on osteoblasts under high glucose environment. Eur Rev Med Pharmacol Sci. 2018 Jan;22(19):6500-6506 Authors: Wang WD, Cheng BZ, Kang WB, Zheng RW, Cai YL, Wang XJ Abstract OBJECTIVE: The occurrence rate of delayed fracture healing in diabetes mellitus patients is high. Transforming growth factor β1 (TGF-β1) is an important regulatory factor in bone tissue repair and regeneration. However, TGF-β1 expression and its function in diabetic patient fracture have not been fully elucidated. PATI...
CONCLUSIONS: Highly expressed FAL1 can promote proliferation and migration of endothelial cells through activating PTEN/AKT signaling pathway. PMID: 30338819 [PubMed - in process]
CONCLUSIONS: Compelling experimental and human work has highlighted the close association connection between endoneurial microangiopathy and diabetic polyneuropathy. Future investigations will need to investigate the role of microvascular factors both in the periphery and the central nervous system in the pathogenesis of painful DPN. PMID: 30338814 [PubMed - in process]
TYPE 2 diabetes sufferers don ’t have to follow strict diet plans, but should watch what they eat so as to avoid a spike in blood sugar levels. Eat this type of birthday cake and follow these tips to ensure you can still enjoy a slice of celebratory cake without harming your blood sugar level.
CONCLUSIONS: In conclusion, exercise-only interventions were effective at lowering the odds of developing GDM, GH and PE. PMID: 30337463 [PubMed - in process]
CONCLUSION: Acute and chronic prenatal exercise reduced maternal circulating blood glucose concentrations, with a larger effect in women with diabetes. PMID: 30337462 [PubMed - in process]
CONCLUSION: in patients with type 2 diabetes mellitus, HbA1c reduction was greater in patients with plant-based diet compared to patients with conventional diet. Further research should be conducted with larger sample size and longer follow-up period. PMID: 30333278 [PubMed - in process]
Laura has not only lost a substantial amount of weight from inflammatory visceral fat resulting in a dramatic reduction in waist size, but has also experienced a reduction in the issues associated with her autoimmune diseases: “I have been on Wheat Belly for about 2 years. I have rheumatoid arthritis and lupus and have seen huge improvements and lowering of meds due to this wonderful plan. So far (and I still need to lose more) I have lost 80 lbs and am still losing. First pic is of me at our high school reunion in 2013 and the next one is today. I think you can see a bit of the difference. I am happy to be down, eve...