Risk of suicidal events with atomoxetine compared to stimulant treatment: a cohort study - Linden S, Bussing R, Kubilis P, Gerhard T, Segal R, Shuster JJ, Winterstein AG.

BACKGROUND: Antidepressant effects on increased suicidality in children have raised public concern in recent years. Approved in 2002 for attention-deficit/hyperactivity disorder treatment, the selective noradrenalin-reuptake-inhibitor atomoxetine was initi...
Source: SafetyLit - Category: Global & Universal Tags: Age: Adolescents Source Type: news

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PURPOSE OF REVIEW The purpose of this article is to present current information on the phenomenology, epidemiology, comorbidities, and pathophysiology of tic disorders and discuss therapy options. It is hoped that a greater understanding of each of these components will provide clinicians with the necessary information to deliver thoughtful and optimal care to affected individuals. RECENT FINDINGS Recent advances include the finding that Tourette syndrome is likely due to a combination of several different genes, both low-effect and larger-effect variants, plus environmental factors. Pathophysiologically, increasing e...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
Conclusions: Bipolar disorder is common among primary care patients presenting with depression; it is often treated exclusively in primary care. Clinicians should be alert for symptoms of bipolar disorder in undiagnosed patients, know what symptoms probabilistically suggest bipolar versus unipolar depression, have expertise in providing ongoing treatment to diagnosed patients, and be knowledgeable about managing common medication-related side effects and comorbidities. Prompt and accurate diagnosis is critical. PMID: 31311335 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
CONCLUSIONS: Suicidal risks were high in mood disorders: ideation was highest with BD type II, attempts and suicides (especially violent) with BD type I. Several risk factors for suicidal acts differed between BD versus MDD patients.Declaration of interestNo author or immediate family member has financial relationships with commercial entities that might appear to represent potential conflicts of interest with the information presented. PMID: 31292010 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
DiscussionAs psychotherapy is among the treatments of choice for most adult psychiatric disorders, a systematic review evaluating the benefits and harms of short-term compared with long-term psychotherapy is urgently needed. It is the hope that this review will be able to inform best practice in treatment and clinical research of these highly prevalent and burdensome disorders.Systematic review registrationPROSPEROCRD42019128535
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
In conclusion, our study identified different developmental trajectories of irritability, including one with characteristics typical of neurodevelopmental/ADHD-like problems—early onset, male preponderance, and clinical and genetic links with ADHD—and one with characteristics typical of depre ssion/mood problems—later onset, female preponderance, and clinical and genetic links with depression,” Riglin and colleagues wrote. “Both groups were associated with risk of adolescent depression, and both were associated with ADHD genetic risk scores. Overall, these findings suggest that the development...
Source: Psychiatr News - Category: Psychiatry Tags: ADHD adolescents attention-deficit/hyperactivity disorder depression disruptive mood dysregulation disorder irritability Lucy Riglin mood disorders neurodevelopmental Source Type: research
In conclusion, this review highlights the importance for clinicians to investigate for the presence of chronic nightmares along with other sleep difficulties (most commonly, insomnia and sleep apnea), to consider the potential influence of nightmares on the course of the primary mental disorder, and to be prepared to grant access to treatments targeting nightmares. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: Dreaming - Category: Psychiatry & Psychology Source Type: research
Abstract The current study examines associations between reactive and proactive aggression and suicidal thoughts and behaviors among youth (N = 115, 62% male), ranging from 6 to 12 years, seeking services in an outpatient psychological clinic. Symptoms of hyperactivity/impulsivity and inattention were evaluated as potential moderators of this link. Children and a caregiver completed self- and parent-report questionnaires on aggression, suicidal behaviors, depressive symptoms, and ADHD-related behaviors during intake. Reactive aggression was more strongly linked to suicidal thoughts and behaviors tha...
Source: Child Psychiatry and Human Development - Category: Child Development Authors: Tags: Child Psychiatry Hum Dev Source Type: research
CONCLUSIONS: Half of those who died by suicide had at least one diagnosed mental health condition in the year before death, and most mental health conditions were associated with an increased risk of suicide. Findings suggest the importance of suicide screening and providing an approach to improve awareness of mental health conditions. PMID: 31185853 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Yes: there are opiates that derive from various food proteins that exert peculiar effects on the human brain. The worst? The opiates that come from the gliadin protein of wheat and related grains. Opiate receptor researchers at the National Institutes of Health originally coined the term “gluteomorphin” nearly 40 years ago when it was determined that the gliadin protein of wheat undergoes partial digestion (since humans lack the digestive enzymes to fully digest proline-rich amino acid sequences in proteins from seeds of grasses) to yield peptides that are 4- to 5-amino acids long. Some of these peptides w...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Opioids addictive binge eating bulimia eating disorders Gliadin opiates wheat belly Source Type: blogs
BACKGROUND: Persons diagnosed with attention-deficit hyperactivity disorder (ADHD) have been found to have an increased risk of suicidal behaviour, but the pathway remains to be thoroughly explored.AimsTo determine whether persons with ADHD are more likely...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
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