UPMC researchers shine light on common heart complication after lung transplantation

(University of Pittsburgh Schools of the Health Sciences) Cardiac arrhythmia is a common complication following lung transplantation, and one that has a significant negative impact on long-term patient survival.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Publication date: Available online 19 July 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Paweł Smykiewicz, Agnieszka Segiet, Michelle Keag, Tymoteusz ŻeraAbstractCardiovascular health deteriorates with age, and age is one of the strongest risk factors for cardiovascular complications including myocardial infarction, heart failure, cardiac arrhythmias, and death related to heart diseases. In this review, we show that expression of proinflammatory cytokines (PICs) increases throughout the human lifespan, and this increase is correlated with cardiovascular health, morbidity, and mortality. We argue that increas...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research
This study thus generated a rat myocardial I/R model to assess the effect on ventricular rhythm and expression of gap junction connexin (Cx43). MATERIAL AND METHODS Male SD rats were randomly assigned into sham, model, and pinocembrin (30 mg/kg) pretreatment groups (N=15 each). The I/R model was generated by ligation of the left anterior descending coronary artery for 30 min. The pinocembrin group received intravenous injection 10 min before surgery. Heart rate (HR), mean artery pressure (MAP), rate pressure product (RPP), and arrhythmia were observed at 10 min before ischemia, 30 min after ischemia, and at 30, 60, and 120...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Haibo Ni, Stefano Morotti, Eleonora Grandi
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Authors: Cirugeda-Roldán EM, Molina Picó A, Novák D, Cuesta-Frau D, Kremen V Abstract Most cardiac arrhythmias can be classified as atrial flutter, focal atrial tachycardia, or atrial fibrillation. They have been usually treated using drugs, but catheter ablation has proven more effective. This is an invasive method devised to destroy the heart tissue that disturbs correct heart rhythm. In order to accurately localise the focus of this disturbance, the acquisition and processing of atrial electrograms form the usual mapping technique. They can be single potentials, double potentials, or complex...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
Authors: He Y, Khan M, Yang J, Yao M, Yu S, Gao H Abstract Cardiac glycosides are natural compounds used for the treatment of congestive heart failure and cardiac arrhythmias. Recently, they have been reported to exhibit anticancer activity. Proscillaridin A (PSN-A), a cardiac glycoside constituent of Urginea maritima has been shown to exhibit anticancer activity. However, the cellular targets and anticancer mechanism of PSN-A in various cancers including prostate cancer remain largely unexplored. In the present study, we have shown that PSN-A inhibits proliferation and induces apoptosis in prostate cancer cells in...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
The relationship between particle matters (PMs) and cardiac arrhythmia has been investigated in numerous studies. However, evidence from developing countries is limited. The aim of this study was to evaluate t...
Source: Environmental Health - Category: Environmental Health Authors: Tags: Research Source Type: research
In this study, we investigated how acellular microheterogeneiti es affect macroscopic conduction under conditions of normal and reduced excitability by utilizing a novel platform of pairedin vitro andin silico studies to examine the mechanisms of conduction. Regular patterns of nonconductive micro-obstacles were created in confluent monolayers of the previously described engineered-excitable Ex293 cell line. Increasing the relative ratio of obstacle size to intra-obstacle strand width resulted in significant conduction slowing up to 23.6% and a significant increase in wavefront curvature anisotropy, a measure of spatial va...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
We report the first case on the use of EVLP followed by separate transplantation in two different centres. The local organ procurement organization proposed the lungs of a 53-year-old non-smoker donor who died for cerebral haemorrhage. P/F ratio was 294 after lung recruitment manoeuvres. Oto score was 10. Two centres accepted the grafts for two single transplantations under the condition of EVLP evaluation. After usual retrieval, the bi-pulmonary block was transferred to Centre 1 and EVLP was run as previously described. At the end of the procedure the two lungs were evaluated separately and both judged suitable for transp...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
AbstractPurposeComorbidities associated with chronic obstructive pulmonary disease (COPD) affect quality of life and increase mortality. Asthma –COPD overlap (ACO) may express a different profile of comorbidities compared to COPD alone. It is unclear how recent changes in GOLD recommendations affect the profile of comorbidities in COPD and ACO.MethodsEight hundred and thirty-four patients with COPD were recruited from 67 Hungarian secondary care outpatient clinics, 469 of them had ACO. Comorbidities were defined by respiratory specialists based on medical history, patient report, and medications. COPD grades were def...
Source: Lung - Category: Respiratory Medicine Source Type: research
In this study we test the hypothesis that an opposite scenario might be plausible in which IP3 ICR is part of an ECC protecting mechanism, resulting in a Ca2+ -dependent anti-arrhythmogenic response on the cellular scale. IP3 R2 activation was triggered via endothelin-1 or IP3 -salt application in single ventricular myocytes from a cardiac-specific IP3 R type 2 overexpressing mouse model. Upon IP3 R2 overexpression, IP3 R activation reduced Ca2+ -wave occurrence (46% vs. 21.72%; P
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
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