UPMC researchers shine light on common heart complication after lung transplantation

(University of Pittsburgh Schools of the Health Sciences) Cardiac arrhythmia is a common complication following lung transplantation, and one that has a significant negative impact on long-term patient survival.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Conditions:   Atrial Fibrillation;   Arrhythmias, Cardiac;   Atrial Flutter Intervention:   Device: Ambulatory ECG Sponsor:   Apple Inc. Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Catheter ablation is the mainstay of treatment in the management of cardiac arrhythmias. The number of catheter ablation procedures performed worldwide in the past 25 years has significantly increased and is expected to increase further. Cardiac ablation requires catheters to be advanced and manipulated within cardiovascular structures. This manipulation has traditionally been performed under fluoroscopic guidance. The advent of 3D electro-anatomic mapping systems (EAM) and intracardiac echocardiography (ICE) has reduced reliance on fluoroscopy.
Source: Radcliffe Cardiology - Category: Cardiology Authors: Source Type: research
Authors: Westerman S, Wenger N Abstract Atrial fibrillation is the most common sustained cardiac arrhythmia. The scope and impact of atrial fibrillation is wide; it can affect cardiac function, functional status, and quality of life, and it confers a stroke risk. There are sex differences in atrial fibrillation across the scope of the disease process, from epidemiology and causative mechanisms to management and outcomes. The approach to management of atrial fibrillation differs between women and men, and there are sex differences in response to medical therapy and catheter ablation. There are many gaps in our knowl...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Conclusion: By introducing the optogenetic sensors chimeric VSFP-butterfly CY and GCaMP6f into the zebrafish we successfully generated an in vivo cellular electrophysiological readout tool for the zebrafish heart. Complementary use of both sensor lines demonstrated the ability to study heart rate, cardiac action potential configuration, spatiotemporal patterning of electrical activation and intracellular Ca2+ homeostasis in embryonic zebrafish. In addition, we demonstrated the first successful use of an optogenetic sensor to study cardiac function in older zebrafish. These models present a promising new research tool to st...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
s Cardona With technological advancement, implanted medical devices can treat a wide range of chronic diseases such as cardiac arrhythmia, deafness, diabetes, etc. Cardiac pacemakers are used to maintain normal heart rhythms. The next generation of these pacemakers is expected to be completely wireless, providing new security threats. Thus, it is critical to secure pacemaker transmissions between legitimate nodes from a third party or an eavesdropper. This work estimates the eavesdropping risk and explores the potential of securing transmissions between leadless capsules inside the heart and the subcutaneous implant un...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Purpose of review Catheter ablations are established treatment options for cardiac arrhythmias. Despite the fact that they are increasingly performed in elderly patients, publications focusing on procedural safety and success concerning this patient subgroup are sparse. The purpose of this review is to inform about current and upcoming studies regarding catheter ablations in the elderly. Recent findings The overall pattern of available studies is indistinct because of varying age limits and scant patient populations. Most studies do not identify advanced patient age as a promoting factor for peri-procedural complicati...
Source: Current Opinion in Cardiology - Category: Cardiology Tags: ARRHYTHMIAS: Edited by Wilber W. Su Source Type: research
Background: Calcium (Ca) is an essential element that plays a critical role in many biological processes. In dialysis patients, the regulation of Ca balance is highly complex, given the absence of kidney function, endocrine disturbances and the use of drugs such as phosphate binders, vitamin D analogues, and calcimimetics. Also, the use of different dialysate Ca (DCa) baths has profound effect on Ca balance, which depends both on the difference between the Ca concentration in the bath and the serum of the patients, as on the ultrafiltration volume.Summary: The choice of DCa may have important short- and long-term consequen...
Source: Blood Purification - Category: Hematology Source Type: research
In this report we describe an atypical phenotype of ATS in 2 related families. We also report our experience with phenytoin sodium for the control of resistant ventricular arrhythmias in these patients.Methods and resultsBetween 2014 and 2018, seven siblings were diagnosed with ATS on the basis of cardiac arrhythmias and genetic evaluation. Heterozygous mutationc.431G  > C (p.G144A) in exon 2 ofKCNJ2 gene was observed in all patients. Characteristic cardiac manifestations were noted in all patients but periodic paralysis or objective neurological involvement was distinctly absent. Phenytoin was considered for ...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
Cardiac arrhythmias (CA) are very common and may occur with or without heart disease. Causes of these disturbances can be components of the metabolic syndrome (MetS) or deficits of micronutrients especially ma...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Research article Source Type: research
AbstractPatients undergoing cardiac surgery are among the most common recipients of allogeneic red blood cell (RBC) transfusions. However, whether restrictive RBC transfusion strategies for cardiac surgery achieve a similar clinical outcome in comparison with liberal strategies remains unclear. We searched electronic databases from inception to December 2017 for randomized controlled trials (RCTs). We calculated the risk ratios (RRs) and weighted-mean difference (MD) using a random-effects model. We included 9 RCTs with a total of 9005 patients. There was no significant difference in mortality between groups [RR 1.03; 95% ...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
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