Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization Microbial Immunity and Vaccines

Streptococcus pneumoniae commonly inhabits the nasopharynx as a member of the commensal biofilm. Infection with respiratory viruses, such as influenza A virus, induces commensal S. pneumoniae to disseminate beyond the nasopharynx and to elicit severe infections of the middle ears, lungs, and blood that are associated with high rates of morbidity and mortality. Current preventive strategies, including the polysaccharide conjugate vaccines, aim to eliminate asymptomatic carriage with vaccine-type pneumococci. However, this has resulted in serotype replacement with, so far, less fit pneumococcal strains, which has changed the nasopharyngeal flora, opening the niche for entry of other virulent pathogens (e.g., Streptococcus pyogenes, Staphylococcus aureus, and potentially Haemophilus influenzae). The long-term effects of these changes are unknown. Here, we present an attractive, alternative preventive approach where we subvert virus-induced pneumococcal disease without interfering with commensal colonization, thus specifically targeting disease-causing organisms. In that regard, pneumococcal surface protein A (PspA), a major surface protein of pneumococci, is a promising vaccine target. Intradermal (i.d.) immunization of mice with recombinant PspA in combination with LT-IIb(T13I), a novel i.d. adjuvant of the type II heat-labile enterotoxin family, elicited strong systemic PspA-specific IgG responses without inducing mucosal anti-PspA IgA responses. This response protected mice f...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Microbial Immunity and Vaccines Source Type: research

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Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
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Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Bill Gates, who is currently on a three-day visit to India, said: "Our biggest work has been broadly in the health area helping to get new vaccines introduced, helping to look at innovations in some of the disease-specific areas, like tuberculosis or visceral leishmaniasis (VL) or lymphatic filariasis (LF)."
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Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
More News: Haemophilus Influenzae (Hib) | Infectious Diseases | Influenza | Influenza Vaccine | Meningitis Vaccine | Otitis | Otitis Media | Pneomococcal Vaccine | Pneumonia | Respiratory Medicine | Staphylococcus Aureus | Vaccines