Study Seeks Women’s Insights on What Works Best for Uterine Fibroids

Contact: Sarah Avery Phone: 919-660-1306 Email: sarah.avery@duke.edu https://www.dukehealth.org FOR IMMEDIATE RELEASE on Monday, May 9, 2016 DURHAM, N.C. – A new registry that launches this month gives women who have uterine fibroids the opportunity to help determine which strategies are most effective in treating the common condition. The registry, called Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF), will enroll more than 10,000 women at clinics affiliated with nine medical centers across the country. Participating women will be asked at annual intervals specific questions about the treatments they’ve elected to receive, and how well the treatments seem to be working for them. Approximately three years after initial treatment, researchers at the Duke Clinical Research Institute (DCRI) will analyze the patients’ feedback to determine which procedures provide the greatest benefit to women – insights that have been lacking for both women and their physicians.  Specifically, studies will focus on symptom relief, reproductive effects, and effectiveness among different patient subgroups, including African-American women, who are disproportionately affected by uterine fibroids. “This is a common condition – it affects up to 75 percent of women to varying degrees and is the leading cause of hysterectomies in the country – yet we don’t know which treatment works best for a given patie...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

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ConclusionThe presence of a uterine scar defect is usually asymptomatic or refers to postmenstrual spotting with dark red or brown discharge, dysmenorrhea, dyspareunia, chronic pelvic pain, infertility or dull sensation following menstruation. Several factors may possibly play a role in isthmocele development such as low uterine incision, deficient suturing technique of the uterine incision, patient-related factors that impair wound healing or increase inflammation or adhesion formation. Different techniques were used as reconstructive therapies of the cesarean scar defect including laparoscopic or robot-assisted laparosco...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
This study will be a pilot, randomized, double-blind, two-arm, placebo-controlled, parallel-group, multicenter clinical trial. Women aged 19 –59 years who present with CHHF will be recruited from five university hospitals. A total of 60 subjects will be randomly assigned to a treatment group (SDT) or a placebo group at a 1:1 ratio. The subjects will receive 3 g of either SDT or placebo three times daily for 8 weeks. The primary o utcome measures will be the Visual Analogue Scale scores of CHHF. The secondary outcome measures will be changes in body temperature in both the hands and the feet as me...
Source: Trials - Category: Research Source Type: clinical trials
In this study we aimed to evaluate the efficacy of extensive hysteroscopic cesarean scar niche excision in symptomatic patients.DesignA retrospective cohort study.PatientsSymptomatic patients treated with hysteroscopic CSD excision who were considered eligible for the procedure when myometrial thickness of 2 mm or more was observed on sonohysterography.SettingTertiary referral center.InterventionsExtensive CSD excision was performed using a cutting loop and pure cutting current. The proximal and distal edges of the defect were resected. This was followed by resection of tissue at the base of the niche, until underling musc...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Uterine fibroids are benign monoclonal neoplasms of the myometrium that represent the most common tumor in reproductive-age women worldwide. Their prevalence is approximately 70% –80% in women by the age of 50 years. Histopathology analysis shows increased smooth muscle cells, collagen, proteoglycans, and fibronectin in a disorganized matter (1). This abnormal proliferation causes anatomic distortion leading to the signs and symptoms present in uterine fibroids, which inc lude abnormal uterine bleeding, pelvic pain, and reproductive dysfunction (impaired implantation, infertility, and spontaneous abortion).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
This article provides an overview of the latest techniques and devices used for uterine-sparing surgical treatment of fibroids. While laparoscopic myomectomy is still the gold standard, novel laparoscopic and transcervical radiofrequency ablation techniques use low-voltage and alternating current to induce heat in the uterine tissue, which triggers necrosis in fibroids. This enables the removal of multiple fibroids without the need for large incisions in the uterine wall. In addition, we address the benefits and potential risks, as well as the impact on fertility and pregnancy, of the different surgical approaches used for...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
In this study we aimed to evaluate the efficacy of extensive hysteroscopic cesarean scar niche excision in symptomatic patients.DesignPatients were followed for a minimum of 1 year following hysteroscopic CSD excision. Clinical information obtained included detailed obstetric history, preoperative and postoperative menstruation pattern.PatientsSymptomatic patients who were treated with hysteroscopic CSD excision. Patients were considered eligible for the procedure in case myometrial thickness of 2mm or more was observed on sonohysterography (SHG)SettingTertiary referral centerInterventionsExtensive CSD excision was perform...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
In this study we aimed to evaluate the efficacy of extensive hysteroscopic cesarean scar niche excision in symptomatic patients.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Original article Source Type: research
In this study we aimed to evaluate the efficacy of extensive hysteroscopic cesarean scar niche excision in symptomatic patients.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: ORIGINAL ARTICLE Source Type: research
Since the early 2000s there has been an ever-increasing awareness of cesarean section scar defects. Much of this is due to increased utilization of pelvic ultrasonography and magnetic resonance imaging and improvements in resolution. Perhaps driving this is a significant increase and prevalence in cesarean sections in the United States, followed by issues with postmenstrual spotting, irregular bleeding, pelvic pain, or infertility. Most studies looking at cesarean scar defects in patients with a history of a prior cesarean section note a prevalence between 24% and 70% when a pelvic ultrasound is done and 56% and 84% when a...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Publication date: Available online 10 February 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Vasilios Tanos, Zara Abigail ToneyAbstractThe increasing rate of elective and indicated caesarean sections worldwide has led to new pathologies and management challenges. The number of patients undergoing trial of labor after caesarean section (TOLAC) is also increasing. Three professional societies provide detailed guidelines based on scientific evidence for the management of patients attempting vaginal birth after caesarean section (VBAC). However, they do not provide any recommendations f...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
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