Study Seeks Women’s Insights on What Works Best for Uterine Fibroids

Contact: Sarah Avery Phone: 919-660-1306 Email: sarah.avery@duke.edu https://www.dukehealth.org FOR IMMEDIATE RELEASE on Monday, May 9, 2016 DURHAM, N.C. – A new registry that launches this month gives women who have uterine fibroids the opportunity to help determine which strategies are most effective in treating the common condition. The registry, called Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF), will enroll more than 10,000 women at clinics affiliated with nine medical centers across the country. Participating women will be asked at annual intervals specific questions about the treatments they’ve elected to receive, and how well the treatments seem to be working for them. Approximately three years after initial treatment, researchers at the Duke Clinical Research Institute (DCRI) will analyze the patients’ feedback to determine which procedures provide the greatest benefit to women – insights that have been lacking for both women and their physicians.  Specifically, studies will focus on symptom relief, reproductive effects, and effectiveness among different patient subgroups, including African-American women, who are disproportionately affected by uterine fibroids. “This is a common condition – it affects up to 75 percent of women to varying degrees and is the leading cause of hysterectomies in the country – yet we don’t know which treatment works best for a given patie...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

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Uterine fibroids (UFs; leiomyomas) are benign monoclonal neoplasms of the myometrium and represent the most common tumors in reproductive-age women worldwide. Tumors occur in approximately 77% of women overall and are clinically manifest in approximately 25% by age 45  years. Although benign, these tumors are nonetheless associated with significant morbidity; they are the primary indication for hysterectomy and a major source of gynecologic and reproductive dysfunction, ranging from profuse menstrual bleeding and pelvic pain to infertility, recurrent miscarriage , and preterm labor.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
(CNN) — People were curious about the keto diet, ALS and endometriosis in 2018. Those are just a few of the health-related topics that had Internet surfers in the United States turning to Dr. Google with questions this year, according to a top 10 list from the search engine giant. The data, based on search terms, was collected from January to mid-December. Last year, some of the top health-related questions searched on Google included what causes hiccups, how to stop snoring, how long flu lasts and what is lupus. Some of the top health-related questions on Google in 2016 were related to Zika, traumatic brain injuries...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat Google Local TV Source Type: news
The objective of this study was to demonstrate a markedly enlarged isthmocele, that resulted in the miscarriage of a 12-week IVF twin pregnancy.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Source Type: research
Objective: Caesarean scar defect, or isthmocele, is a reservoir type pouch on the anterior wall of the uterine isthmus caused by inappropriate healing of the lower segment incision after caesarean section. The incidence of caesarean scar defects is reported to be as high as 84%, and is increasing due to the rising rates of caesarean sections worldwide. Caesarean scar defects may be asymptomatic, or cause a number of gynaecologic and obstetric sequealae, including abnormal bleeding, pelvic pain, infertility and ectopic scar pregnancy.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Source Type: research
Conclusion: The patients of SLCT can present with hormonal magnification and manifest high AFP, CA125, and T levels. SLCT is characterized by a solid or mixed solid-cystic mass on CT/MR scans, and shows marked or moderated heterogeneous and constantly enhancement upon postcontrast study. The clinical characteristics and imaging findings are features and appropriated imaging should be performed whenever an SLCT is suspected.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conditions:   Abnormal Uterine Bleeding;   Chronic Pelvic Pain;   Infertility, Female Intervention:   Drug: Misoprostol 200 mcg 2 Tab Sponsor:   Rajavithi Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Uterine myomas are common benign monoclonal tumors with extremely low potential for malignancy. They are estimated to be present in up to 70% of women of reproductive age [1], with a higher incidence in obese women and those of African American descent, and when symptomatic, a frequent indication for gynecologic surgery. Although the presence of myomas may be associated with a plethora of symptoms including pelvic pain, abnormal uterine bleeding, infertility/subfertility, and adverse pregnancy outcomes [2], the vast majority of women with uterine fibroids are asymptomatic.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Perspective Source Type: research
Uterine myomas are common benign monoclonal tumors with extremely low potential for malignancy. They are estimated to be present in up to 70% of women of reproductive age [1], with a higher incidence in obese women and those of African American descent and, when symptomatic, a frequent indication for gynecologic surgery. Although the presence of myomas may be associated with a plethora of symptoms including pelvic pain, abnormal uterine bleeding, infertility/subfertility, and adverse pregnancy outcomes [2], the vast majority of women with uterine myomas are asymptomatic.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Perspectives Source Type: research
​BY GREGORY TAYLOR, DO, &JACKLYN MCPARLANE​, DOA 31-year-old woman with a significant medical history for one ectopic pregnancy and five spontaneous abortions presented with abdominal pain and vaginal bleeding. Her symptoms started abruptly two days earlier, and the pain was located in the right lower quadrant, which had become diffuse and she described as sharp. She was also experiencing nausea, vomiting, and vaginal bleeding.She stated she had been spotting for five days and soaking up to four pads a day. Her last menstrual period was two months before, and a home pregnancy test was positive. Her presentation was...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
We report the case of a 28-year-old nulliparous female with unexplained infertility who underwent freeze-all vaginal oocyte retrieval. Twenty-one days later she presented with vaginal bleeding (similar to menstruation) and right lower-quadrant pain. The results of ultrasound scanning and a laboratory work-up were consistent with an ectopic pregnancy. She underwent laparoscopic right salpingectomy for a tubal ectopic pregnancy. We recommend sexual abstinence during assisted reproduction to lower the risk of multiple pregnancy and especially of heterotopic pregnancy.
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
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