The effect of Iresine herbstii Hook on some haematological parameters of experimentally induced anaemic rats

Abstract Iresine herbstii is fed to livestock in South-eastern Nigeria in the belief that it boosts their blood supply. The aim of this work is to study the effect of the methanolic extract of I. herbstii Hook on some blood parameters of experimentally induced anaemic albino rats. For acute toxicity study, graded doses of the methanolic leaf extract of I. herbstii at 10, 100, 1000, 1600, 2900 and 5000 mg/kg were administered orally to rats randomly allotted to six groups of three animals each and signs of toxicity were observed for 24 h. To evaluate its haematological effects, 100, 200, and 400 mg/kg of extract was administered orally to three out of five groups of six rats each for 14 days after the induction of acute blood loss anaemia. Parameters monitored were packed cell volume (PCV), haemoglobin concentration (Hb), weight gain and red blood cell counts (RBC). Phytochemical, proximate and nutritional analysis of the plant was done. I. herbstii had an LD50 > 5000 mg/kg. Mean group weight gain and RBC were significantly (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: Available online 21 August 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Chi-Ching Chen, Shui-Yi Tung, Kuo-Liang Wei, Chien-Heng Shen, Te-Sheng Chang, Wei-Ming Chen, Huang-Wei Xu, Chih-Wei Yen, Yi-Hsing Chen, Sheng-Nan Lu, Chao-Hung HungBackground/PurposeThe major dose-limiting toxicity of ribavirin is hemolytic anemia. We investigated the incidence, risk factors and impact on virological response of anemia in chronic hepatitis C genotype 2 patients receiving sofosbuvir plus ribavirin therapy.MethodsThis was a retrospective real-world analysis of a single center including 293 chronic h...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
This study was designed to determine the factors influencing the use of anaemia preventing measures among antenatal clinic attendees in the Kintampo North Municipality, Ghana. A cross sectional study was conducted among pregnant women attending the clinics after 36 weeks of pregnancy. Demographic data and information on use of all interventions were obtained using a structured questionnaire. The factors associated with the use of the interventions were identified using multiple logistic regression. The use of all anemia preventing interventions among pregnant women was found to be 30%. The study identified that use of all ...
Source: African Journal of Reproductive Health - Category: African Health Tags: Afr J Reprod Health Source Type: research
AbstractPurpose of ReviewThe purpose of this update is to summarize the recent advances on the management of cerebral venous thrombosis (CVT).Recent FindingsThere is a trend in declining frequency of CVT patients presenting with focal deficits or coma and a decrease in mortality over time. Anemia and obesity were identified as risk factors for CVT. During pregnancy and puerperium, the higher risk of CVT occurs in the first months post-delivery. With appropriate management, 1/3 of comatose CVT patients can have a full recovery.SummaryThe management of CVT patients includes treatment of associated conditions, anticoagulation...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
In conclusion, LMNPs demonstrate superiority as a therapeutic regimen for the treatment of IDA among the tested iron formulations.
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSION: Low-dose rituximab has good efficacy and safety in the treatment of hematologic abnormalities in patients with connective tissue disease.
. PMID: 31426902 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
DiscussionIt is anticipated that eligible studies will consist of small observational studies. Evidence gathered from this review will provide the first broader understanding of the clinical features, outcomes, prognosis, and management of snakebite-associated thrombotic microangiopathy.Systematic review registrationPROSPERO CRD42019121436
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
This study was registered at www.clinicaltrials.gov as #NCT02519452.
Source: Blood - Category: Hematology Authors: Tags: Multiple Myeloma, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
This study assessed whether the AG patients with hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than AG patients without hyperhomocysteinemia or healthy control subjects.MethodsThe blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 127 AG patients with hyperhomocysteinemia, 937 AG patients without hyperhomocysteinemia, and 532 healthy control subjects were measured and compared.ResultsWe found that 127 AG patients with hyperhomocysteinemia had significantly higher frequencies...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Staphylococcal scalded skin syndrome (SSSS) is a skin blistering condition caused by the release of exotoxins by Staphylococcus aureus. Greater mortality and complications have been associated with adult SSSS as compared with pediatric SSSS. 827 patients of patients diagnosed with SSSS were investigated from 20032012 in the National Inpatient Sample (NIS). Adult patients ( ≥18 years) consisted of 28% of the patient population. Adult SSSS patients had significantly greater rates of Agency for Healthcare Research and Quality (AHRQ) standardized comorbidities including: deficiency anemia (P
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Due to the limited data on the correlation of age and atopic dermatitis, elderly patients with atopic dermatitis were investigated for inpatient complications. Atopic dermatitis patient cases were analyzed using the National Inpatient Sample (NIS) database from 2003 to 2012. Elderly ( ≥65 years) and nonelderly adult atopic dermatitis or eczema patients were analyzed for differences in hospital complications and comorbidities. 1355 (33.7%) of the 4017 patients identified were elderly. Elderly patients had significantly higher rates of Agency for Healthcare Research and Quality ( AHRQ) standardized comorbidities including...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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