Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes.

In conclusion, the current results suggest that activation of SIRT3 substantially ameliorates the detrimental effects of TP by closing the mPTP. PMID: 27064125 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27064125?dopt=Abstract

Source: Toxicology in Vitro - April 6, 2016 Category: Toxicology Authors: Yang Y, Wang W, Xiong Z, Kong J, Qiu Y, Shen F, Huang Z Tags: Toxicol In Vitro Source Type: research