Novel Multiple Sclerosis Genetic Risk Factors Are Involved in Epigenetic Regulation (S37.006)

Conclusions: Our GWAS approach in a defined population with limited substructure allowed identification of associations not found in larger, more heterogeneous cohorts, and thus provides new clues to the pathogenesis of MS.Disclosure: Dr. Buck has nothing to disclose. Dr. Andlauer has nothing to disclose. Dr. Bayas has received personal compensation for activities with Merck Serono, Biogen-Idec, Novartis and Sanofi/Genzyme as a speaker/consultant. Dr. Berger has received research support from the German Migraine and Headache Society. Dr. Berthele has nothing to disclose. Dr. Binder has nothing to disclose. Dr. Dankwoski has nothing to disclose. Dr. Franke has nothing to disclose. Dr. Gold has received research support from Bayer HealthCare, Biogen Idec, Merck Serono, Novartis, and Teva Neuroscience. Dr. Herms has nothing to disclose. Dr. Homuth has nothing to disclose. Dr. Joeckel has nothing to disclose. Dr. Kacprowski has nothing to disclose. Dr. Kieseier holds stock and/or stock options in Biogen, which sponsored research in which Dr. Kieseier was involved as an investigator. Dr Kümpfel has received personal compensation for activities with Bayer Healthcare, Teva Pharma, Merck-Serono, Novartis Pharma, Sanofi-Aventis, Genzyme, and Biogen-Idec. Dr. Laudes has nothing to disclose. Dr. Lieb has nothing to disclose. Dr. Limmroth has received personal compensation for activities with Bayer Pharmaceuticals Inc., Biogen Idec, Novartis, Roche Diagnostics Corp., Sanofi-Aventis ...

Source: Neurology - February 7, 2016 Category: Neurology Authors: Buck, D., Andlauer, T., Bayas, A., Berger, K., Berthele, A., Binder, E., Dankwoski, T., Franke, A., Gold, R., Herms, S., Homuth, G., Joeckel, K.-H., Kacprowski, T., Kieseier, B., Kuempfel, T., Laudes, M., Lieb, W., Limmroth, V., Linker, R., Moebus, S., Mu Tags: Risk Factors for Multiple Sclerosis Source Type: research