Suppression of plasma free fatty acids reduces myocardial lipid content and systolic function in type 2 diabetes

Type 2 diabetes (T2DM) is closely associated with the development of heart failure, which might be related with impaired substrate metabolism and accumulation of myocardial lipids (MYCL). The aim of this study was to investigate the impact of an acute pharmacological inhibition of adipose tissue lipolysis leading to reduced availability of circulating FFA on MYCL and heart function in T2DM.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 29, 2016 Category: Nutrition Authors: Peter Wolf, Yvonne Winhofer, Martin Krssak, Sabina Smajis, Jürgen Harreiter, Lana Kosi-Trebotic, Clemens Fürnsinn, Christian-Heinz Anderwald, Sabina Baumgartner-Parzer, Siegfried Trattnig, Anton Luger, Michael Krebs Source Type: research