Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome.

In conclusion, we suggest screening for GATA2 mutations in pediatric myelodysplastic syndrome, preferentially in patients with impaired B cell homeostasis in bone marrow and peripheral blood (low number of progenitors, intronRSS-Kde recombination excision circles and naive cells). PMID: 27013649 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27013649?dopt=Abstract

Source: Haematologica - March 23, 2016 Category: Hematology Authors: Novakova M, Zaliova M, Sukova M, Wlodarski M, Janda A, Fronkova E, Campr V, Lejhancova K, Zapletal O, Pospisilova D, Cerna Z, Kuhn T, Svec P, Pelkova V, Zemanova Z, Kerndrup G, van den Heuvel-Eibrink M, van der Velden V, Niemeyer C, Kalina T, Trka J, Star Tags: Haematologica Source Type: research