Id: 113: the endothelial phd2/hif-2 axis regulates pulmonary artery pressure in mice

Conclusions
Our studies identify endothelial HIF-2 as a key transcription factor in the pathogenesis of PH and suggest that HIF-2 regulates PA pressure by modulating the expression of vasoactive molecules. Our findings identify the PHD2/HIF2 axis as a potential target for PH therapies.

Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Kapitsinou, P., Rajendran, G., Astleford, L., Schonfeld, M., Michael, M., Shay, S., French, J., West, J., Haase, V., Fields, T. Tags: Pulmonary/Critical Care Source Type: research