Sodium nitroprusside has leishmanicidal activity independent of iNOS

CONCLUSIONS: Sodium nitroprusside enhances microbicidal activity in Leishmania -infected macrophages by boosting nitric oxide and 3-nitrotyrosine.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

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Publication date: Available online 15 August 2019Source: Veterinary ParasitologyAuthor(s): Ana Vitória Verde Oliveira Rocha, Brenda Fernanda Sodré Moreno, Aline Diniz Cabral, Nayara Mendes Louzeiro, Leandro Macedo Miranda, Vivian Magalhães Brandão dos Santos, Francisco Borges Costa, Rita de Maria Seabra Nogueira, Arlei Marcili, Márcia Aparecida Sperança, Andréa Pereira da CostaAbstractVisceral leishmaniasis is a zoonotic disease caused by Leishmania infantum for which dogs are the main reservoir. In South America, presence of this disease is expanding along with increasing d...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Canine leishmaniosis is a disease caused by Leishmania infantum, a vector-borne parasite. Due to the zoonotic potential of canine leishmaniosis, infected dogs must be identified. Serological assays are the most c...
Source: Acta Veterinaria Scandinavica - Category: Veterinary Research Authors: Tags: Brief communication Source Type: research
Phlebotomine sand flies (Diptera: Psychodidae) are haematophagous insects that transmit the protozoan parasite Leishmania infantum (Kinetoplastida: Trypanosomatidae), the main causative agent of both zoonotic vis...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
The parasite Leishmania infantum causes zoonotic visceral leishmaniasis (VL), a potentially fatal vector-borne disease of canids and humans. Zoonotic VL poses a significant risk to public health, with regions of ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Authors: Sofizadeh A, Hanafi-Bojd AA, Shoraka HR Abstract Background &objectives: Zoonotic cutaneous leishmaniasis (ZCL) is among the most endemic zoonotic diseases in Golestan Province of Iran. The aim of this study was to find the high risk areas of this infection by considering the distribution of reservoirs and human infection. Methods: A cross-sectional study was conducted, in which Rhombomys opimus (Gerbils) were captured from different collection sites across the Golestan Province, Iran. records about the occurrence of Rh. opimus in the Province was obtained from earlier studies and were gathered in ...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Publication date: Available online 16 March 2019Source: Parasitology InternationalAuthor(s): K. Gonzalez, J.E. Calzada, R. Díaz, H. Paz, Victor García, A. Miranda, T. Tomokane, S. Puga, A. Saldaña, M. LaurentiAbstractCutaneous leishmaniasis (CL) is one of the most frequent parasitic zoonoses in Panama. Currently, conventional, molecular and histopathological tests are performed to diagnose CL. Immunohistochemistry (IHC) has proven to be a valuable tool to facilitate the diagnosis of leishmaniasis and to study the cellular immune response developed during the infection. Therefore, considering the absenc...
Source: Parasitology International - Category: Parasitology Source Type: research
Abstract Cutaneous leishmaniasis is a parasitic infection caused by a flagellated parasite belonging to the genus Leishmania. In most cases, it is a zoonotic disease transmitted via a bite by bloodsucking sand-flies of the genus Phlebotomus. The disease reservoirs consist of wild or semi-domesticated animals, generally rodents or dogs. The disease itself is distributed extensively worldwide in the Americas, Asia, Europe and Africa. Epidemiology is affected by environmental, migratory and climatic factors. Identification of the different types of leishmaniasis is based chiefly on the biochemical characteristics (is...
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
Publication date: May 2019Source: Biomedicine &Pharmacotherapy, Volume 113Author(s): Allan Henrique Depieri Cataneo, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, João Paulo Assolini, Carolina Panis, Danielle Kian, Lucy Megumi Yamauchi, Andrea Name Colado Simão, Rubia Casagrande, Phileno Pinge-Filho, Idessania Nazareth Costa, Waldiceu Ap. Verri, Ivete Conchon-Costa, Wander Rogério PavanelliAbstractAmerican cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus Leishmania. The treatment of cutaneous leishmaniasis is unsatisfactory, thus, much research effort ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
li WR Abstract American cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus Leishmania. The treatment of cutaneous leishmaniasis is unsatisfactory, thus, much research effort has been focused on investigating new compounds with lower collateral effects to the patients and derived from low-cost sources, such as natural products. In the present study, we evaluated the in vitro directly effect of the flavonoid quercetin against Leishmania (Viannia) braziliensis. Quercetin inhibited the proliferation of promastigote forms at all tested concentrations, these effect were due to increasing the...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
In this study, 269 dogs suffering from CanL that were presented by their owners to the clinic of the National School of Veterinary Medicine of Sidi Thabet (Tunisia), were examined. Male dogs were more infected than female dogs (sex-ratio = 1.53). The age distribution in dogs has a normal distribution; mostly animals less than 4 years old (48.7%) gets affected by this disease. The majority of the animals were German Shepherded (14.4%) followed by Staffordshire (12.6%) and Rottweiler (9.6%). Most of the dogs live outdoor (87%), did not receive any acaricidal treatment (88.5%) and were not dewormed (70.3%). Poor body conditio...
Source: Bulletin de la Societe de Pathologie Exotique - Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research
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