Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity

Conclusion
ATM-regulated effects within cardiac fibroblasts are pivotal in Dox-induced cardiotoxicity, and antagonism of ATM and its functions may have potential therapeutic implications.

Source: Cardiovascular Research - March 18, 2016 Category: Cardiology Authors: Zhan, H., Aizawa, K., Sun, J., Tomida, S., Otsu, K., Conway, S. J., Mckinnon, P. J., Manabe, I., Komuro, I., Miyagawa, K., Nagai, R., Suzuki, T. Tags: Cardiac biology and remodelling Source Type: research