Hidden in plain sight: Well-known drug could yield new treatment for herpes viruses

(University of Utah Health Sciences) In a search for new antiviral drugs, University of Utah scientists found that a common heart failure medicine, spironolactone, has an unexpected ability to block Epstein Barr virus (EBV). The drug blocks a key step in viral infection common to all herpesviruses, revealing that it could be developed into a new class of drug to treat infections caused by herpesviruses including herpes, shingles, and mono. The research was published in PNAS.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Publication date: Available online 15 October 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jason J. Woods, Kathryn A. Skelding, Kristy L. Martin, Ritambhara Aryal, Estelle Sontag, Daniel M. Johnstone, Jay C. Horvat, Philip M. Hansbro, Elizabeth A. MilwardAbstractAlzheimer’s disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
ConclusionsSOPs may provide a good starting point for increasing adult immunization coverage rates. Using additional interventions, quality-based metrics, or incentives could lead to sustained adult immunization prioritization.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
In this study, we aimed to evaluate the differential impact of DM2 on all-cause mortality in men vs women with HFpEF after admission for acute HF.MethodsWe prospectively included 1019 consecutive HFpEF patients discharged after admission for acute HF in a single tertiary referral hospital. Multivariate Cox regression analysis was used to evaluate the interaction between sex and DM2 regarding the risk of long-term all-cause mortality. Risk estimates were calculated as hazard ratios (HR).ResultsThe mean age of the cohort was 75.6 ± 9.5 years and 609 (59.8%) were women. The proportion of DM2 was similar betwe...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
ConclusionsThe results of the BRAKE-AF project might allow inclusion of ivabradine within the limited arsenal of drugs currently available for rate control in AF.Clinical trial registration: http://www.clinicaltrials.gov. Identifier: NCT03718273.ResumenIntroducción y objetivosLa ivabradina es un inhibidor de la corriente If, principal determinante de la función marcapasos del nódulo sinusal, aprobado como antianginoso y para tratar la insuficiencia cardiaca. Existen indicios sobre su capacidad para inhibir la conducción a través del nódulo auriculoventricular (NAV). Sobre esta base...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 16 October 2019Source: Canadian Journal of CardiologyAuthor(s): Sattler Katherine, El-Battrawy Ibrahim, Gietzen Thorsten, Kummer Marvin, Lang Siegfried, Zhou Xiao-bo, Behnes Michael, Borggrefe Martin, Akin IbrahimAbstractBackgroundCardiogenic shock (1) is a severe complication of myocardial infarction (MI) or of takotsubo syndrome. For both diseases, CS is related to a worse long term outcome. Outcome of CS has not been studied in a direct comparison of MI patients and TTS patients.Methods and ResultsMortality and cardiovascular complications were compared in patients presenting with CS b...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Authors: Lee SH, Hon KL, Chiu WK, Ting YW, Lam SY Abstract OBJECTIVES: There is no guideline in Hong Kong regarding respiratory syncytial virus (RSV) immunoprophylaxis for children with heart disease because of a lack of local data on RSV infection. Therefore, this study evaluated the epidemiology and impact of RSV infection on children with heart disease in Hong Kong, with the goal of providing recommendations regarding RSV immunoprophylaxis. METHODS: This multicentre retrospective case-control study on paediatric RSV infection was conducted in four local regional hospitals from 2013 to 2015. The patients' dem...
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
Abstract PURPOSE: To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart failure. METHODS: Pressure overload-induced heart failure model (abdominal aortic coarctation) was established in 40 rats, which were divided into model and 5, 10 and 20 mg/kg TIIA groups. Ten rats receiving laparotomy excepting abdominal aortic coarctation were enrolled in sham-operated group. The 5, 10 and 20 mg/kg TIIA groups were treated with 5, 10 and 20 mg/kg TIIA, respectively, for 8 weeks. RESULTS: Compared with model group, in 20 mg/kg TIIA group the left ve...
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
Contributors : Yuto Nakamura ; Shunbun Kita ; Yoshimitsu Tanaka ; Shiro Fukuda ; Yoshinari Obata ; Tomonori Okita ; Yusuke Kawachi ; Yuri Shimizu-Tsugawa ; Yuya Fujishima ; Hitoshi Nishizawa ; Atusko Sehara ; Norikazu Maeda ; Iichiro ShimomuraSeries Type : Expression profiling by arrayOrganism : Mus musculusTo investigated global changes caused by pressure overload-induced heart failure in ADAM12 knockout mice using a microarray analysis.A disintegrin and metalloproteinase (ADAM) 12 is has long been considered to promote cardiac dysfunction based on according to the finding report that a small molecule ADAM12 inhibitor, KB...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Publication date: Available online 16 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Vasundhara Kain, Ganesh V. HaladeAbstractAmplified innate leukocytes (neutrophils and monocytes/macrophages) are associated with advanced ischemic and non-ischemic heart failure (HF). Intensified neutrophilic leukocytosis (neutrophilia) and sustained activation of neutrophils is the predominant factor that determines over activated inflammation in acute HF and the outcome of long-term chronic HF. After heart attack, the first wave of innate responsive and short-lived neutrophils is essential for the initiation of inflammation...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
To the Editor Le and Rothberg recently assessed the cost-effectiveness of the adjuvanted herpes zoster subunit vaccine in a population of older adults, finding that it was cost-effective at the commonly accepted willingness-to-pay threshold of $50  000 per quality-adjusted life-year. In their analyses, the authors accounted for not only the costs of the vaccine and the benefits associated with the prevention of herpes zoster but also the costs and decreased quality of life associated with adverse effects. In an accompanying editorial, Najaf zadeh discussed the evolution and value of the herpes zoster vaccine. However, in...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
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