Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis.

CONCLUSION: In SALS, and especially in classic ALS, the changes in motor protein expression may alter bidirectional intracellular transport in PBMCs. More studies are needed to find out whether the levels of KIF5C and DCTN1 may be useful in ALS diagnosis, and whether KIF1B expression may discriminate ALS from ALS-mimicking disorders. PMID: 26954557 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26954557?dopt=Abstract

Source: Neuro-Degenerative Diseases - March 9, 2016 Category: Neurology Authors: Kuźma-Kozakiewicz M, Kaźmierczak B, Chudy A, Gajewska B, Barańczyk-Kuźma A Tags: Neurodegener Dis Source Type: research