Auditory functional magnetic resonance in awake (nonsedated) and propofol‐sedated children

ConclusionsAfter auditory stimuli, propofol‐sedated 5‐ to 8‐year‐old children exhibit an fMRI cortical activation pattern which is different from that in similarly aged nonsedated children.
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: Research Report Source Type: research

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Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Emma Christiaen, Marie-Gabrielle Goossens, Robrecht Raedt, Benedicte Descamps, Lars Emil Larsen, Erine Craey, Evelien Carrette, Kristl Vonck, Paul Boon, Christian VanhoveAbstractEpilepsy is a neurological disorder characterized by recurrent epileptic seizures. Electrophysiological and neuroimaging studies in patients with epilepsy suggest that abnormal functional brain networks play a role in the development of epilepsy, i.e. epileptogenesis, resulting in the generation of spontaneous seizures and cognitive impairment. In this longitudinal study, we...
Source: NeuroImage - Category: Neuroscience Source Type: research
Conclusions: The characteristic EEG pattern in the acute phase promoted timely diagnosis of FIRES. Our data suggest that KD may be a safe and promising therapy for FIRES with SRSE, and that early initiation of KD produces a favorable prognosis. Therefore, KD should be applied earlier in the course of FIRES. Intravenous KD can be an effective alternative route of administration for patients who may not take KD enterally. Introduction Febrile infection-related epilepsy syndrome (FIRES) is a rare epileptic encephalopathy of unknown etiology which occurs in patients without active epilepsy or underlying neurological diso...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Joong-Goo Kim1,2, Han-Bin Lee2 and Sang-Beom Jeon2* 1Department of Neurology, Jeju National University Hospital, Jeju, South Korea 2Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Objectives: The use of dexmedetomidine and ketamine (DEX–KET) combination for magnetic resonance imaging (MRI) sedation has not been evaluated. We investigated the efficacy and safety of DEX–KET for sedation of patients undergoing MRI of the brain. Methods: This quasi-experimental study was conducted to compare the DEX–KET combination and midazolam for MRI sed...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we compared the dynamic resting-state local and large-scale FC between PTSD patients (n = 22) and healthy controls (HC; n = 22; conducted as standard deviation in resting-state local and large-scale FC over a series of sliding windows). Local dynamic FC was examined by calculating the dynamic regional homogeneity (dReHo), and large-scale dynamic FC (dFC) was investigated between regions with significant dReHo group differences. For the PTSD patients, we also investigated the relationship between symptom severity and dFC/dReHo. Our results showed that PTSD patients were characterized by I) increased dynamic (...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionsWe report a rare case of giant prolactinoma with a first epileptic seizure immediately after the initiation of dopamine agonist therapy. Clinicians need to be aware that the rapid reduction of a giant prolactinoma by dopamine agonist therapy may cause an epileptic seizure.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
(J Clin Anesth. 2018;44:123–124) In this correspondence, the authors described a patient who presented with simultaneous pneumocephalus and cavernoma after receiving combined spinal-epidural analgesia for labor. However, unlike most cases of combined spinal-epidural analgesia for labor, which use loss of resistance to air to identify the epidural space, the authors used loss of resistance to saline. To the author’s knowledge, there are no published reports of the use of loss of resistance to saline for this purpose. Identification of the epidural space was successful upon the fourth attempt with the patient in...
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Case Reports Source Type: research
ConclusionOur case supports the efficacy of immunotherapies for NORSE even though it does not manifest definite evidence for autoimmune background. Clinicians should consider these immunotherapies for NORSE as early as possible, because this condition is associated with high mortality and morbidity owing to prolonged seizure activity and long-term intensive care including general anesthesia and mechanical ventilation.
Source: Journal of Intensive Care - Category: Intensive Care Source Type: research
Conclusion TBI is a distinct and complex pathophysiological entity. Neurocognitive deficits and mood disorders are common sequelae of TBI. While nonmodifiable factors influence risk of developing post-TBI depression, there is also evidence that biological factors are involved. People who have suffered TBI are at increased risk for ictal events and cognitive impairment. ECT has been documented to successfully treat patients with post-TBI mood symptoms in only three published cases. While these vignettes suggest that ECT might be a safe and effective therapeutic option in treating individuals with post-TBI depression, more r...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Hot Topics in Neuroscience depression ECT Electroconvulsive therapy mood disorders TBI traumatic brain injury treatments Source Type: research
AbstractBackgroundNuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving.Sources of dataThe data presented comes from clinical experience and some milestone papers on the subject.Areas of agreementNuclear medicine imaging is well-established in paediatric nephro-urology in the context of urinary tract infection, ante-natally diagnos...
Source: British Medical Bulletin - Category: General Medicine Source Type: research
AbstractA biomarker that will enable the identification of patients at high-risk for developing post-injury epilepsy is critically required. Microvascular pathology and related blood –brain barrier dysfunction and neuroinflammation were shown to be associated with epileptogenesis after injury. Here we used prospective, longitudinal magnetic resonance imaging to quantitatively follow blood–brain barrier pathology in rats following status epilepticus, late electrocorticography to identify epileptic animals and post-mortem immunohistochemistry to confirm blood–brain barrier dysfunction and neuroinflammation....
Source: Brain - Category: Neurology Source Type: research
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