Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction

ConclusionsTranscriptome changes likely affect neuron structure and function, leading to behavioral anomalies consistent with both ADHD and addiction phenotypes. The data should further motivate analyses of Lphn3 function in the developmental timing of altered gene expression and calcium signaling, and their effects on neuronal structure/function during development. LPHN3 has been associated with both ADHD and vulnerability to addiction. We evaluated a Lphn3 null mouse and observed changes in behavior that encompass both activity levels and reward motivation. We also observe altered serum calcium levels; neurite outgrowth; and neurotransmitter levels. Further, our data indicate that loss of Lphn3 leads to developmentally dynamic alterations in the transcriptome and suggest that cell adhesion molecules and calcium‐dependent signaling proteins are affected. These transcriptomic and neuronal changes in structure and function are anticipated to affect the brain as a whole and further result in changes in behavior.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research