TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

Conclusions
TGR5 is an important mediator of BA-induced cholangiocyte proliferation in vivo and in vitro. Furthermore, TGR5 protects cholangiocytes from death receptor-mediated apoptosis. These mechanisms may protect cholangiocytes from BA toxicity under cholestatic conditions, however, they may trigger proliferation and apoptosis resistance in malignantly transformed cholangiocytes, thus promoting CCA progression.

Source: Gut - February 12, 2016 Category: Gastroenterology Authors: Reich, M., Deutschmann, K., Sommerfeld, A., Klindt, C., Kluge, S., Kubitz, R., Ullmer, C., Knoefel, W. T., Herebian, D., Mayatepek, E., Häussinger, D., Keitel, V. Tags: Pancreas and biliary tract, Hepatic cancer Hepatology Source Type: research