The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice
Conclusions
We propose that, in the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways.
Source: Gut - Category: Gastroenterology Authors: Martinelli, P., Madriles, F., Canamero, M., Pau, E. C.-d. S., Pozo, N. d., Guerra, C., Real, F. X. Tags: Pancreas and biliary tract Source Type: research
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