The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice

Conclusions We propose that, in the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways.
Source: Gut - Category: Gastroenterology Authors: Tags: Pancreas and biliary tract Source Type: research