The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon

Conclusions The CD-risk allele, Thr300Ala, in ATG16L1 is associated with improved overall survival in human CRC, generating a rationale to genotype ATG16L1 Thr300Ala in patients with CRC. We found that Thr300A alters production of MAVS-dependent type I IFN in CRC cells, providing a mechanism that may influence clinical outcomes.

http://gut.bmj.com/cgi/content/short/65/3/456?rss=1

Source: Gut - February 12, 2016 Category: Gastroenterology Authors: Grimm, W. A., Messer, J. S., Murphy, S. F., Nero, T., Lodolce, J. P., Weber, C. R., Logsdon, M. F., Bartulis, S., Sylvester, B. E., Springer, A., Dougherty, U., Niewold, T. B., Kupfer, S. S., Ellis, N., Huo, D., Bissonnette, M., Boone, D. L. Tags: Crohn's disease, Open access, Colon cancer Source Type: research