A phase II study of cediranib, an oral VEGF inhibitor, in previously untreated patients with metastatic or recurrent malignant melanoma

Conclusions Although 2 patients had stable disease at 6 months, the short median time to progression and lack of any objective responses indicate that single agent cediranib at this dose and schedule is not sufficiently active to warrant study continuation.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ04551A, PaperYitong Xie, Di Wei, Tian Hu, Yajing Hou, Yuanyuan Lin, Huaizhen He, Cheng Wang Uncaria rhynchophylla (UR) is a widely used traditional Chinese herb for hyperpyrexia, epilepsy, preeclampsia, and hypertension. In this paper, the potential anti-pseudo-allergic components in UR were explored. Six alkaloids in... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addi tion, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.
Source: Surgical Oncology Clinics of North America - Category: Surgery Authors: Source Type: research
This article reviews the newest and most up-to-date advances in precision medicine within melanoma practice.
Source: Surgical Oncology Clinics of North America - Category: Surgery Authors: Source Type: research
ConclusionsThe best management strategy of RIBP is prevention by reducing total RT doses and close follow-up. However, when RIBP occurs, we recommend treatment with HBO therapy, steroids, trental, and vitamin E as tolerable.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
es MA Abstract The sympathetic nervous system (SNS) regulates body functions in normal and pathological conditions and is characterized by the presence of a neuroplastic phenomenon, termed ganglionic long-term potentiation (gLTP). In hypertension, either in spontaneously hypertensive rats (SHR) or in humans, sympathetic hyperfunction, such as elevated SNS outflow and changes in synaptic plasticity have been described. Because enhanced SNS outflow is detected in the hypertensive stage and, more importantly, in the prehypertensive phase of SHR, here we explored whether synaptic plasticity, particularly gLTP, was mod...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
s N Abstract Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitive impairment. Long-term hypertension, complicated or not by the occurrence of ischemic stroke, is often reviewed on its vascular side, and parenchymal consequences are put aside. Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron conne...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
HIGH blood pressure is prevalent in the UK, with more than one in four people living with the condition, yet many people will not realise it. The best way to keep your blood pressure in check is to make healthy dietary decisions, and in addition to eating certain foods, a number of drinks have been associated with lowering blood pressure.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionWith simple network structure like RBFN and SVM we were able to obtain results better than other complex networks.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Effect of Body Weight Change on Blood Pressure in a Japanese General Population with a Body Mass Index ≥ 22 kg/m2. Int Heart J. 2019 Nov 15;: Authors: Itoh H, Kaneko H, Kiriyama H, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yamamichi N, Komuro I Abstract The association between changes in body weight and blood pressure (BP) in overweight people in the general population still remains unclear. We sought to clarify the effect of body weight change on BP using a community-based cohort. We studied 1,170 overweight subjects with a body mass index (BMI) ≥ 22 kg/m2 who underwent health check-ups. Among ...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
In this study, we examined the role of SMP30 in pulmonary vasculature using SMP30-deficient mice.We used female SMP30-deficient mice and wild-type littermate (WT) mice at the age of 12 to 18 weeks. The WT and SMP30-deficient mice were exposed to normoxia or hypoxia (10% oxygen for 4 weeks). In normoxia, the right ventricular systolic pressure (RVSP) was not different between the WT and SMP30-deficient mice, but in hypoxia, the RVSP was significantly higher in the SMP30-deficient mice compared to the WT mice (P
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
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