Loss of plakoglobin immunoreactivity in intercalated discs in arrhythmogenic right ventricular cardiomyopathy: protein mislocalization versus epitope masking

Conclusions Reduced plakoglobin staining in intercalated discs of heart tissue from human ARVC patients and in a murine ARVC model is caused by alterations in epitope accessibility and not by protein relocalization.

http://cardiovascres.oxfordjournals.org/cgi/content/short/109/2/260?rss=1

Source: Cardiovascular Research - January 25, 2016 Category: Cardiology Authors: Kant, S., Krusche, C. A., Gaertner, A., Milting, H., Leube, R. E. Tags: Cardiac biology and remodelling Source Type: research