Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

Conclusions
As expected, treatment with anti-inflammatory drugs leads to smaller infarct size in large animal MI models. Timing of outcome assessment, sex, and study quality are significantly associated with outcome and may explain part of the translational failure in clinical settings. Effect size depends on the type of drug used, enabling identification of compounds for future clinical testing.

Source: Cardiovascular Research - January 25, 2016 Category: Cardiology Authors: van Hout, G. P. J., Jansen of Lorkeers, S. J., Wever, K. E., Sena, E. S., Kouwenberg, L. H. J. A., van Solinge, W. W., Macleod, M. R., Doevendans, P. A., Pasterkamp, G., Chamuleau, S. A. J., Hoefer, I. E. Tags: Cardiac biology and remodelling Source Type: research