Abstract B38: Melatonin efficacy in breast cancer microenvironment under acidosis

In conclusion, our results show that acute acidosis reduces the viability of breast cancer cells and melatonin treatment is effective, leading to decrease the cell viability under acute acidosis.In addition, studies are being madeto evaluate the effectiveness of melatonin also in chronic acidosis conditions, and to investigate its signaling pathways in the extreme tumor microenvironment, in order to confirm potential effectiveness of melatonin in breast cancer in these conditions.Citation Format: Nathália Martins Sonehara, Bruna Victorasso Jardim-Perassi, André de Lima Mota, Marina Gobbe Moschetta, Debora Aparecida Pires de Campos Zuccari, Rubens de Paula, Jr. Melatonin efficacy in breast cancer microenvironment under acidosis. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr B38.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Alterations of Nutrient/Fuel Sensing in Cancer: Poster Presentations - Proffered Abstracts Source Type: research