Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy.

Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy.
Auton Neurosci. 2015 Dec 9;
Authors: Karam C
Abstract
The author presents a patient with Harlequin and Horner syndromes as part of an autoimmune autonomic ganglionopathy and suggests implication for work-up and management. In general, Harlequin and Horner syndromes are reported to be caused by either a structural lesion of the sympathetic pathway or, when no structural lesion is found, are presumed to be idiopathic. In this paper, a 76year old man developed a Harlequin and Horner syndromes in the setting of subacute autonomic failure and other systemic features. The patient's symptoms improved with a short course of intravenous methylprednisolone. An autoimmune etiology should be considered in patients with Harlequin syndrome and immunomodulatory treatment could be attempted, especially when there is evidence of a more generalized autoimmune autonomic ganglionopathy.
PMID: 26704065 [PubMed - as supplied by publisher]

Source: Autonomic Neuroscience - December 9, 2015 Category: Neuroscience Authors: Karam C Tags: Auton Neurosci Source Type: research