Olfactory dysfunction in Multiple Sclerosis: A scoping review of the literature

Conclusions The overall weight of the literature suggests that olfactory dysfunction may occur in MS. Although there is variability in reported frequency, the more robust studies suggest the prevalence is significant, ranging from 20% to 45% in the MS population. Despite this, the mechanisms are unknown and the clinical relevance of this association has not been well explored. Interesting findings relating mood disorders, cognition, and olfactory dysfunction in MS are also suggested but remain poorly developed and require further investigation. Future studies are also warranted to understand the dynamic changes in olfactory function during the course of MS, and to correlate olfactory function with relapses/disease activity.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research