Inorganic Arsenic Related Changes in the Stromal Tumor Microenvironment in a Prostate Cancer Cell–Conditioned Media Model

Conclusions: Our results suggest a concentration-dependent alteration of stromal signaling, specifically attenuation of stromal-mediated TGFβ signaling following exposure to iAs. Our results indicate iAs may enhance prostate cancer cell viability through a previously unreported stromal-based mechanism. These findings illustrate that the stroma may mediate the effects of iAs in tumor progression, which may have future therapeutic implications. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Shearer JJ, Wold EA, Umbaugh CS, Lichti CF, Nilsson CL, Figueiredo ML. Inorganic Arsenic Related Changes in the Stromal Tumor Microenvironment in a Prostate Cancer Cell–Conditioned Media Model. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510090 Received: 17 April 2015 Accepted: 12 November 2015 Advance Publication: 20 November 2015 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Suppl...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research