Viruses, Vol. 7, Pages 5476-5488: Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France

Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing piece of the puzzle is the current distribution and the genetic variation of PUUV in France, which has been overlooked until now and remains poorly understood. During a population survey, from 2008 to 2011, bank voles were trapped in eight different forests of France located in areas known to be endemic for NE or in area from where no NE case has been reported until now. Bank voles were tested for immunoglobulin (Ig)G ELISA serology and two seropositive animals for each of three different areas (Ardennes, Jura and Orleans) were then subjected to laboratory analyses in order to sequence the whole S, M and L segments of PUUV. Phylogenetic analyses revealed that French PUUV isolates globally belong to the central European (CE) lineage although isolates from Ardennes are clearly distinct from those in Jura and Orleans, suggesting a different evolutionary history and origin of PUUV introduction in France. Sequence analyses revealed specific amino acid signatures along the N protein, including in PUUV from the Orleans region from where NE in humans has never been reported. The relevance of these mutations in term of pathophysiology is discussed.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research

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Authors: Babiker A, Gaifer Z Abstract Cystic echinococcosis (CE) is a zoonotic infection caused by the tapeworm of the genus Echinococcus, a cestode endemic in many parts of the world. CE can affect any organ, with the lung being the second most commonly affected organ after the liver. For the management of pulmonary CE, guidelines recommend surgical resection of cysts with adjuvant anti-helminthic therapy. In cases where surgery is not possible, medical therapy alone can be used. However, to date, there is a paucity of data to advocate for one modality over the other. Here, we report two cases of pulmonary CE caus...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Authors: Rahim MA, Zaman S, Amin MR, Uddin KN, Ma JC Abstract Histoplasmosis is uncommon in many parts of the world, including Bangladesh, where, in recent years, cases are increasingly reported. We sought to describe the sociodemographic characteristics, clinical presentation, investigations, treatment, and outcome of histoplasmosis in Bangladesh. We conducted a retrospective data review of published literature from 1962 to 2017, containing information on histoplasmosis in and/or from Bangladesh. Unpublished, well-documented histoplasmosis cases were also included. A total of 26 male patients aged 8-75 years, with...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
by Yidan Li, Bernard Cazelles, Guoqing Yang, Marko Laine, Zheng X. Y. Huang, Jun Cai, Hua Tan, Nils Chr. Stenseth, Huaiyu Tian Seoul hantavirus (SEOV) has recently raised concern by causing geographic range expansion of hemorrhagic fever with renal syndrome (HFRS). SEOV infections in humans are significantly underestimated worldwide and epidemic dynamics of SEOV-related HFRS are poorly understood because of a lack of fiel d data and empirically validated models. Here, we use mathematical models to examine both intrinsic and extrinsic drivers of disease transmission from animal (the Norway rat) to humans in a SEOV-endemic ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Viruses, Vol. 11, Pages 675: Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica Viruses doi: 10.3390/v11070675 Authors: Konstantin Kletenkov Ekaterina Martynova Yuriy Davidyuk Emmanuel Kabwe Anton Shamsutdinov Ekaterina Garanina Venera Shakirova Ilsiyar Khaertynova Vladimir Anokhin Rachael Tarlinton Albert Rizvanov Svetlana Khaiboullina Sergey Morzunov Nephropathia Epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) and linked to hantavirus infection, is endemic in the Republic of Tatarstan. Several genetic markers of HFRS severity have been i...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionsThe clinical course of acute NE was similar in adults and children with high frequency of AKI as well as thrombocytopenia, but with full recovery of all patients.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conclusions/significanceThe southeastern and central Shandong Province are current key HFRS epidemic foci dominated byA.agrarius andR.norvegicus, respectively. Our study could help local departments to strengthen prevention and control measures in key areas to reduce the hazards of HFRS.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Urbanization and rural-urban migration are two factors driving global patterns of disease and mortality. There is significant concern about their potential impact on disease burden and the effectiveness of current control approaches. Few attempts have been made to increase our understanding of the relationship between urbanization and disease dynamics, although it is generally believed that urban living has contributed to reductions in communicable disease burden in industrialized countries. To investigate this relationship, we carried out spatiotemporal analyses using a 48-year-long dataset of hemorrhagi...
Source: Rural Remote Health - Category: Rural Health Authors: Tags: Proc Natl Acad Sci U S A Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
(Kazan Federal University) Hantavirus infection is acute zoonosis clinically manifesting in two forms: Hemorrhagic Fever with Renal Syndrome (HFRS), caused by Old World hantaviruses, and Hantavirus pulmonary syndrome (HPS), caused by New World hantaviruses. Mild form of HFRS, Nephropaia epidemica (NE), is diagnosed in Tatarstan region of Russia, while HPS is endemic in Americas. Humans become infected by inhaling virus contaminated aerosol of urine and feces.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
In this study, we investigated viral RNA from 76 tissues samples (lung n=30, heart n=6, liver n=18 and kidney n=22) of infected naturall rodent hosts in the area of Central Dinarides caught in live traps. Puumala virus was extracted from 34,7% (16/46) rodents by nested reverse transcriptase polymerase chain reaction (RT-PCR) and real-time RT-PCR. Overall, 18 (21,4%) specimens of internal organs (kidney n=8, liver n=6, heart n=2 and lung n=2) were positive for PUUV. It was shown a high rodent infestation rate in a relatively low number of rodent and their organs, although mice were not caught during the time of high density...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
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